Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids
Joint Authors
Pinna, Roberto
Milia, Egle
Delitala, Alessandro P.
Maioli, Margherita
Basoli, Valentina
Santaniello, Sara
Cruciani, Sara
Grillari-Voglauer, Regina
Fontani, Vania
Rinaldi, Salvatore
Muggironi, Roberta
Pigliaru, Gianfranco
Ventura, Carlo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Human dental pulp stem cells (hDPSCs) have shown relevant potential for cell therapy in the orthopedic and odontoiatric fields.
The optimization of their osteogenic potential is currently a major challenge.
Vascular endothelial growth factor A (VEGF A) has been recently reported to act as a major conductor of osteogenesis in vitro and in vivo.
Here, we attempted to prime endogenous VEGF A expression without the need for viral vector mediated gene transfer technologies.
We show that hDPSCs exposure to a mixture of hyaluronic, butyric, and retinoic acids (HA + BU + RA) induced the transcription of a gene program of osteogenesis and the acquirement of an osteogenic lineage.
Such response was also elicited by cell exposure to melatonin, a pleiotropic agent that recently emerged as a remarkable osteogenic inducer.
Interestingly, the commitment to the osteogenic fate was synergistically enhanced by the combinatorial exposure to a conditioned medium containing both melatonin and HA + BU + RA.
These in vitro results suggest that in vivo osteogenesis might be improved and further studies are needed.
American Psychological Association (APA)
Maioli, Margherita& Basoli, Valentina& Santaniello, Sara& Cruciani, Sara& Delitala, Alessandro P.& Pinna, Roberto…[et al.]. 2016. Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116179
Modern Language Association (MLA)
Maioli, Margherita…[et al.]. Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116179
American Medical Association (AMA)
Maioli, Margherita& Basoli, Valentina& Santaniello, Sara& Cruciani, Sara& Delitala, Alessandro P.& Pinna, Roberto…[et al.]. Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116179