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Decellularized Extracellular Matrix as an In Vitro Model to Study the Comprehensive Roles of the ECM in Stem Cell Differentiation
Joint Authors
Tanaka, Masaru
Chen, Guoping
Hoshiba, Takashi
Endo, Chiho
Maruyama, Hiroka
Wakui, Miyuki
Nemoto, Eri
Kawazoe, Naoki
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Stem cells are a promising cell source for regenerative medicine.
Stem cell differentiation must be regulated for applications in regenerative medicine.
Stem cells are surrounded by extracellular matrix (ECM) in vivo.
The ECM is composed of many types of proteins and glycosaminoglycans that assemble into a complex structure.
The assembly of ECM molecules influences stem cell differentiation through orchestrated intracellular signaling activated by many ECM molecules.
Therefore, it is important to understand the comprehensive role of the ECM in stem cell differentiation as well as the functions of the individual ECM molecules.
Decellularized ECM is a useful in vitro model for studying the comprehensive roles of ECM because it retains a native-like structure and composition.
Decellularized ECM can be obtained from in vivo tissue ECM or ECM fabricated by cells cultured in vitro.
It is important to select the correct decellularized ECM because each type has different properties.
In this review, tissue-derived and cell-derived decellularized ECMs are compared as in vitro ECM models to examine the comprehensive roles of the ECM in stem cell differentiation.
We also summarize recent studies using decellularized ECM to determine the comprehensive roles of the ECM in stem cell differentiation.
American Psychological Association (APA)
Hoshiba, Takashi& Chen, Guoping& Endo, Chiho& Maruyama, Hiroka& Wakui, Miyuki& Nemoto, Eri…[et al.]. 2015. Decellularized Extracellular Matrix as an In Vitro Model to Study the Comprehensive Roles of the ECM in Stem Cell Differentiation. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116917
Modern Language Association (MLA)
Hoshiba, Takashi…[et al.]. Decellularized Extracellular Matrix as an In Vitro Model to Study the Comprehensive Roles of the ECM in Stem Cell Differentiation. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1116917
American Medical Association (AMA)
Hoshiba, Takashi& Chen, Guoping& Endo, Chiho& Maruyama, Hiroka& Wakui, Miyuki& Nemoto, Eri…[et al.]. Decellularized Extracellular Matrix as an In Vitro Model to Study the Comprehensive Roles of the ECM in Stem Cell Differentiation. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116917
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116917