Quantification of Rifaximin in Tablets by Spectrophotometric Method Ecofriendly in Ultraviolet Region
Joint Authors
Salgado, Hérida Regina Nunes
Kogawa, Ana Carolina
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Rifaximin is an oral nonabsorbable antibiotic that acts locally in the gastrointestinal tract with minimal systemic adverse effects.
It does not have spectrophotometric method ecofriendly in the ultraviolet region described in official compendiums and literature.
The analytical techniques for determination of rifaximin reported in the literature require large amount of time to release results and are significantly onerous.
Furthermore, they use toxic reagents both for the operator and environment and, therefore, cannot be considered environmentally friendly analytical techniques.
The objective of this study was to develop and validate an ecofriendly spectrophotometric method in the ultraviolet region to quantify rifaximin in tablets.
The method was validated, showing linearity, selectivity, precision, accuracy, and robustness.
It was linear over the concentration range of 10–30 mg L−1 with correlation coefficients greater than 0.9999 and limits of detection and quantification of 1.39 and 4.22 mg L−1, respectively.
The validated method is useful and applied for the routine quality control of rifaximin, since it is simple with inexpensive conditions and fast in the release of results, optimizes analysts and equipment, and uses environmentally friendly solvents, being considered a green method, which does not prejudice either the operator or the environment.
American Psychological Association (APA)
Kogawa, Ana Carolina& Salgado, Hérida Regina Nunes. 2016. Quantification of Rifaximin in Tablets by Spectrophotometric Method Ecofriendly in Ultraviolet Region. Scientifica،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117621
Modern Language Association (MLA)
Kogawa, Ana Carolina& Salgado, Hérida Regina Nunes. Quantification of Rifaximin in Tablets by Spectrophotometric Method Ecofriendly in Ultraviolet Region. Scientifica No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1117621
American Medical Association (AMA)
Kogawa, Ana Carolina& Salgado, Hérida Regina Nunes. Quantification of Rifaximin in Tablets by Spectrophotometric Method Ecofriendly in Ultraviolet Region. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117621