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Increased Blood Pressure Variability Is Associated with Worse Neurologic Outcome in Acute Anterior Circulation Ischemic Stroke
Joint Authors
Tirschwell, David
Bennett, Alicia
Stoddard, Gregory J.
Smith, Gordon
Wang, Haimei
Wold, Jana
Chung, Lee
Majersik, Jennifer J.
de Havenon, Adam
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Although research suggests that blood pressure variability (BPV) is detrimental in the weeks to months after acute ischemic stroke, it has not been adequately studied in the acute setting.
Methods.
We reviewed acute ischemic stroke patients from 2007 to 2014 with anterior circulation stroke.
Mean blood pressure and three BPV indices (standard deviation, coefficient of variation, and successive variation) for the intervals 0–24, 0–72, and 0–120 hours after admission were correlated with follow-up modified Rankin Scale (mRS) in ordinal logistic regression models.
The correlation between BPV and mRS was further analyzed by terciles of clinically informative stratifications.
Results.
Two hundred and fifteen patients met inclusion criteria.
At all time intervals, increased systolic BPV was associated with higher mRS, but the relationship was not significant for diastolic BPV or mean blood pressure.
This association was strongest in patients with proximal stroke parent artery vessel occlusion and lower mean blood pressure.
Conclusion.
Increased early systolic BPV is associated with worse neurologic outcome after ischemic stroke.
This association is strongest in patients with lower mean blood pressure and proximal vessel occlusion, often despite endovascular or thrombolytic therapy.
This hypothesis-generating dataset suggests potential benefit for interventions aimed at reducing BPV in this patient population.
American Psychological Association (APA)
de Havenon, Adam& Bennett, Alicia& Stoddard, Gregory J.& Smith, Gordon& Wang, Haimei& Wold, Jana…[et al.]. 2016. Increased Blood Pressure Variability Is Associated with Worse Neurologic Outcome in Acute Anterior Circulation Ischemic Stroke. Stroke Research and Treatment،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1118494
Modern Language Association (MLA)
de Havenon, Adam…[et al.]. Increased Blood Pressure Variability Is Associated with Worse Neurologic Outcome in Acute Anterior Circulation Ischemic Stroke. Stroke Research and Treatment No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1118494
American Medical Association (AMA)
de Havenon, Adam& Bennett, Alicia& Stoddard, Gregory J.& Smith, Gordon& Wang, Haimei& Wold, Jana…[et al.]. Increased Blood Pressure Variability Is Associated with Worse Neurologic Outcome in Acute Anterior Circulation Ischemic Stroke. Stroke Research and Treatment. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1118494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1118494