Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol
Joint Authors
Quintans-Júnior, Lucindo José
Dantas, Milla Gabriela Belarmino
Reis, Silvio Alan Gonçalves Bomfim
Damasceno, Camila Mahara Dias
Rolim, Larissa Araújo
Rolim-Neto, Pedro José
Carvalho, Ferdinando Oliveira
Almeida, Jackson Roberto Guedes da Silva
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-09
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Borneol is a bicyclic monoterpenoid alcohol commonly used in traditional Chinese and Indian medicine.
It is extracted from the essential oil of various medicinal plants.
It has antibacterial, analgesic, and anti-inflammatory action proven in studies that used oral and intraperitoneal applications of this monoterpene in mice.
The current study was designed to develop a topical gel formulation containing the monoterpene borneol using carbopol as gel base and to evaluate its stability.
The prepared formulation was subjected to physical characterization and physical-chemistry assessment.
The gel was prepared from carbopol and 5% of borneol.
The prepared gel was subjected to pharmacotechnical tests such as its pH, viscosity, conductivity, spreadability, centrifugation, and accelerated stability with freezing-thaw cycle.
The borneol was successfully incorporated into the carbopol formulation.
Borneol gel (BG5) showed good stability after eight months of its development and after 12 days in the freeze-thaw cycle, not showing statistical difference in pH value, conductivity, and viscosity before and after test.
Furthermore, the formulation showed a good spreadability.
Therefore, it was concluded that the formulation could be very promising alternative for the topical or transdermal treatment of skin diseases.
American Psychological Association (APA)
Dantas, Milla Gabriela Belarmino& Reis, Silvio Alan Gonçalves Bomfim& Damasceno, Camila Mahara Dias& Rolim, Larissa Araújo& Rolim-Neto, Pedro José& Carvalho, Ferdinando Oliveira…[et al.]. 2016. Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol. The Scientific World Journal،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1120567
Modern Language Association (MLA)
Dantas, Milla Gabriela Belarmino…[et al.]. Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol. The Scientific World Journal No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1120567
American Medical Association (AMA)
Dantas, Milla Gabriela Belarmino& Reis, Silvio Alan Gonçalves Bomfim& Damasceno, Camila Mahara Dias& Rolim, Larissa Araújo& Rolim-Neto, Pedro José& Carvalho, Ferdinando Oliveira…[et al.]. Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol. The Scientific World Journal. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1120567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1120567