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Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release
Joint Authors
Lodhi, Bilal Ahmad
Hussain, Muhammad Ajaz
Sher, Muhammad
Haseeb, Muhammad Tahir
Ashraf, Muhammad Umer
Hussain, Syed Zajif
Bukhari, Syed Nasir Abbas
Hussain, Irshad
Source
Advances in Polymer Technology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study is carried out on polysaccharide-based hydrogel extracted from the seeds of Ocimum basilicum L.
for its evaluation as a superabsorbent and stimuli responsive biomaterial for sustained release drug delivery system.
O.
basilicum (Syn: Basil) seed hydrogel (BSH) expressed high swelling capacity at pH 6.8 and 7.4 and deionized water.
Highly reversible on-off switching (swelling-deswelling) behavior of BSH was ascertained in deionized water and ethanol, pH 7.4 and 1.2, and deionized water and normal saline.
Scanning electron microscopy (SEM) of BSH has revealed macroporous structure of BSH having average pore size of 1.92 ± 3.83 μm noted after swelling and lyophilization.
BSH containing tablet formulations showed a sustained release pattern of diclofenac sodium (DS) which is dependent on the concentration of BSH.
When comparing with commercially available formulation of DS, even better sustained release behavior of DS was observed in BSH-based formulation.
Super case-II transport mechanism is followed by the DS release from BSH matrix tablet.
Haemocompatibility studies of BSH were also performed and found it nonhaemolytic and nonthrombogenic.
American Psychological Association (APA)
Lodhi, Bilal Ahmad& Hussain, Muhammad Ajaz& Sher, Muhammad& Haseeb, Muhammad Tahir& Ashraf, Muhammad Umer& Hussain, Syed Zajif…[et al.]. 2019. Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release. Advances in Polymer Technology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1122211
Modern Language Association (MLA)
Lodhi, Bilal Ahmad…[et al.]. Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release. Advances in Polymer Technology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1122211
American Medical Association (AMA)
Lodhi, Bilal Ahmad& Hussain, Muhammad Ajaz& Sher, Muhammad& Haseeb, Muhammad Tahir& Ashraf, Muhammad Umer& Hussain, Syed Zajif…[et al.]. Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release. Advances in Polymer Technology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1122211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1122211