The Removal of HBV in Plasma by Extracorporeal Immunoadsorption from Plasma: A Potential Therapy of Hepatitis B Patients
Joint Authors
Han, Zhenwei
Lu, Xuan
Tang, Yiping
Yang, Yuanyuan
Liu, Qiuchen
Cheng, Pengfei
Zhou, Li
Wang, Yefu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To establish a novel HBV specific immunoadsorbent for the removing of HBV particles.
Methods.
The anti-HBsAg monoclonal antibody was immobilized on sepharose beads to produce a sepharose anti-HBs column.
Then the immunoadsorbent was evaluated and characterized by scanning electron microscopy.
In addition, time-dependent effects of the eradication capacity of anti-HBsAg functionalized sepharose beads against HBV were investigated.
Results.
Proposed immunoadsorbents exhibited a favorable biocompatibility as well as specificity.
With the optimized recycle time, the decontamination performance of HBV particles and quantity of HBsAg were assessed either by real-time quantitative PCR or ELISA, which showed that the immunoadsorbent could remove approximately 90% of the HBV and 90% of the HBsAg from human plasma samples.
Conclusions.
All these results indicated that the novel immunoadsorbent could effectively remove HBV particles and likely serve as a novel therapy option or at least supplementary for the treatment regimen of HBV.
American Psychological Association (APA)
Han, Zhenwei& Lu, Xuan& Tang, Yiping& Yang, Yuanyuan& Liu, Qiuchen& Cheng, Pengfei…[et al.]. 2018. The Removal of HBV in Plasma by Extracorporeal Immunoadsorption from Plasma: A Potential Therapy of Hepatitis B Patients. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1124205
Modern Language Association (MLA)
Han, Zhenwei…[et al.]. The Removal of HBV in Plasma by Extracorporeal Immunoadsorption from Plasma: A Potential Therapy of Hepatitis B Patients. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1124205
American Medical Association (AMA)
Han, Zhenwei& Lu, Xuan& Tang, Yiping& Yang, Yuanyuan& Liu, Qiuchen& Cheng, Pengfei…[et al.]. The Removal of HBV in Plasma by Extracorporeal Immunoadsorption from Plasma: A Potential Therapy of Hepatitis B Patients. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1124205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124205