Chronic Consumption of Sweeteners and Its Effect on Glycaemia, Cytokines, Hormones, and Lymphocytes of GALT in CD1 Mice
Joint Authors
Escoto, Jorge
Ramírez Durán, Ninfa
Valdés-Ramos, Roxana
Martínez-Carrillo, Beatríz E.
Rosales-Gómez, Cristian Angel
Reséndiz-Albor, Aldo Arturo
Mondragón-Velásquez, Talia
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
The consumption of sweeteners has increased in recent years, being used to control body weight and blood glucose.
However, they can cause increased appetite, modification of immune function, and secretion of hormones in the GALT.
Objective.
To assess the effect of chronic sweetener consumption on glycaemia, cytokines, hormones, and GALT lymphocytes in CD1 mice.
Material and Methods.
72 CD1 mice divided into 3 groups were used: (a) baseline, (b) middle, and (c) final.
Groups (b) and (c) were divided into 4 subgroups: (i) Control, (ii) Sucrose, (iii) Sucralose, and (iv) Stevia.
The following were determined: body weight, hormones (GIP, insulin, and leptin), lymphocytes CD3+T cells and CD19+B cells, IgA+ plasma cells, and cytokines (IL-4, IL-5, IFN-γ, and TNF-α).
Results.
Sucralose reduces secretion of GIP and glycaemia but does not modify insulin concentration, increases body weight, and reduces food intake.
Stevia increases the secretion of GIP, insulin, leptin, body weight, and glycaemia but keeps food consumption normal.
Sucralose and Stevia showed a higher percentage of CD3+T cells, CD19+B cells, and IgA+ plasma cells in Peyer’s patches, but only Stevia in lamina propria.
Conclusion.
Sweeteners modulate the hormonal response of cytokines and the proliferation of lymphocytes in the intestinal mucosa.
American Psychological Association (APA)
Rosales-Gómez, Cristian Angel& Martínez-Carrillo, Beatríz E.& Reséndiz-Albor, Aldo Arturo& Ramírez Durán, Ninfa& Valdés-Ramos, Roxana& Mondragón-Velásquez, Talia…[et al.]. 2018. Chronic Consumption of Sweeteners and Its Effect on Glycaemia, Cytokines, Hormones, and Lymphocytes of GALT in CD1 Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1124251
Modern Language Association (MLA)
Rosales-Gómez, Cristian Angel…[et al.]. Chronic Consumption of Sweeteners and Its Effect on Glycaemia, Cytokines, Hormones, and Lymphocytes of GALT in CD1 Mice. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1124251
American Medical Association (AMA)
Rosales-Gómez, Cristian Angel& Martínez-Carrillo, Beatríz E.& Reséndiz-Albor, Aldo Arturo& Ramírez Durán, Ninfa& Valdés-Ramos, Roxana& Mondragón-Velásquez, Talia…[et al.]. Chronic Consumption of Sweeteners and Its Effect on Glycaemia, Cytokines, Hormones, and Lymphocytes of GALT in CD1 Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1124251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124251