Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents
Joint Authors
Alokail, Majed
Al-Daghri, Nasser M.
Bukhari, Ihtisham
Yakout, Sobhy M.
Khattak, Malak N. K.
Aziz, Ibrahim
Sabico, Shaun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Nitric oxide (NOx) is an important biomolecule which interacts with other molecules including 25(OH)D to mediate various metabolic pathways.
Interactions and associations of NOx with 25(OH)D have been well studied both in vitro and in vivo, yet associations in apparently healthy adolescents have never been studied.
Methods.
A total of 740 (245 boys and 495 girls) apparently healthy Saudi adolescents aged 10-17 years were included in this cross-sectional study, to determine the associations of NOx with 25(OH)D and other biomarkers in Saudi adolescents.
Serum NOx, 25(OH)D, and other biochemical and anthropometric parameters were measured following standard protocols and manufacturers’ guidelines.
Results.
NOx level was significantly higher in boys than girls (p<0.001).
In all subjects, NOx showed a significant inverse correlation with 25(OH)D.
After stratification according to sex however this significant association was observed only in boys and not in girls.
NOx was also significantly associated with BMI, serum triglycerides, and systolic blood pressure in all subjects.
Conclusion.
The significantly inverse association of NOx and 25(OH)D among apparently healthy adolescents is influenced by sex and further strengthens the extraskeletal role of 25(OH)D in maintaining endothelial homeostasis in this age group, particularly in boys.
Whether vitamin D correction can influence NOx production over time among adolescents remains to be proven.
American Psychological Association (APA)
Al-Daghri, Nasser M.& Bukhari, Ihtisham& Yakout, Sobhy M.& Sabico, Shaun& Khattak, Malak N. K.& Aziz, Ibrahim…[et al.]. 2018. Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1124358
Modern Language Association (MLA)
Al-Daghri, Nasser M.…[et al.]. Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1124358
American Medical Association (AMA)
Al-Daghri, Nasser M.& Bukhari, Ihtisham& Yakout, Sobhy M.& Sabico, Shaun& Khattak, Malak N. K.& Aziz, Ibrahim…[et al.]. Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1124358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124358