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Disease Sequences High-Accuracy Alignment Based on the Precision Medicine
Joint Authors
Shen, Youjian
Li, ManZhi
Long, HaiXia
Wang, HongTao
Fu, HaiYan
Xu, Dong
Liao, Bo
Yao, Yuhua
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
High-accuracy alignment of sequences with disease information contributes to disease treatment and prevention.
The results of multiple sequence alignment depend on the parameters of the objective function, including gap open penalties (GOP), gap extension penalties (GEP), and substitution matrix (SM).
Firstly, the theory parameter formulas relating to GOP, GAP, and SM are inferred, combining unaligned sequence length, number, and identity.
Secondly, we tested the rationality of the theory parameter formulas, with experiment on the ClustalW and MAFFT program.
In addition, we obtained a group of MAFFT program parameters according to the formulas proposed.
The results of all experiments show that the SPS (sum-of-pair score) obtained from theory parameters is better than the SPS obtained from the default parameters of ClustalW and MAFFT.
In both theory and practice, our method to determine the parameters is feasible and efficient.
These can provide high-accuracy alignment results for precision medicine.
American Psychological Association (APA)
Li, ManZhi& Long, HaiXia& Wang, HongTao& Fu, HaiYan& Xu, Dong& Shen, Youjian…[et al.]. 2018. Disease Sequences High-Accuracy Alignment Based on the Precision Medicine. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1124598
Modern Language Association (MLA)
Li, ManZhi…[et al.]. Disease Sequences High-Accuracy Alignment Based on the Precision Medicine. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1124598
American Medical Association (AMA)
Li, ManZhi& Long, HaiXia& Wang, HongTao& Fu, HaiYan& Xu, Dong& Shen, Youjian…[et al.]. Disease Sequences High-Accuracy Alignment Based on the Precision Medicine. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1124598
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124598