Dittrichia viscosa L. Ethanolic Extract Based Ointment with Antiradical, Antioxidant, and Healing Wound Activities
Joint Authors
Rhimi, Wafa
Hlel, Raoudha
Ben Salem, Issam
Boulila, Abdennacer
Rejeb, Ahmed
Saidi, Mouldi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dittrichia viscosa which belongs to the Asteraceae family is frequently used to treat hematomas and skin disorders in Mediterranean herbal medicine.
This study aims to validate its antioxidant effects and its potential on healing wounds.
The ethanolic extract of D.
viscosa leaves was formulated as 2.5% and 5% (w/w) in ointment bases on the beeswax and sesame oil.
During this study, the ethanolic D.
viscosa extract, ointments containing 2.5% and 5% of D.
viscosa extract, and the vehiculum were assessed for their total phenol content (TPC), caffeoylquinic acid content (CQC), and antioxidant activities using complementary methods (TAC, the DPPH, ABTS, FRAP, and the BCB).
The effects on wound healing of obtained ointments were evaluated by excision of the wound in a mice model for 12 days.
Subsequently, the excised wound areas were measured at the 3rd, 9th, and 12th days.
The skin tissues were isolated for histological studies.
The ointments containing D.
viscosa extract (2.5%, 5%) possessed a considerable TPC, CQC, radical scavenging potential, and antioxidant activities compared to the vehiculum.
Treated animals with ointments containing D.
viscosa extract at 2.5% and 5% showed almost and totally healed wounds compared to the vehiculum and control groups, evidenced by good skin regeneration and reepithelialization.
The present work showed the role of D.
viscosa antioxidants exerted by its polyphenolic compounds, in particular, caffeoylquinic acids, in enhancing wound healing.
American Psychological Association (APA)
Rhimi, Wafa& Hlel, Raoudha& Ben Salem, Issam& Boulila, Abdennacer& Rejeb, Ahmed& Saidi, Mouldi. 2019. Dittrichia viscosa L. Ethanolic Extract Based Ointment with Antiradical, Antioxidant, and Healing Wound Activities. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125121
Modern Language Association (MLA)
Rhimi, Wafa…[et al.]. Dittrichia viscosa L. Ethanolic Extract Based Ointment with Antiradical, Antioxidant, and Healing Wound Activities. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1125121
American Medical Association (AMA)
Rhimi, Wafa& Hlel, Raoudha& Ben Salem, Issam& Boulila, Abdennacer& Rejeb, Ahmed& Saidi, Mouldi. Dittrichia viscosa L. Ethanolic Extract Based Ointment with Antiradical, Antioxidant, and Healing Wound Activities. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125121
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125121