Serum Trace Elements Profile in Graves’ Disease Patients with or without Orbitopathy in Northeast China
Joint Authors
Mao, Jinyuan
Xie, Xiaochen
Teng, Weiping
Guan, Haixia
Qin, Jing
Liu, Yongping
Li, Yushu
Peng, Shiqiao
Liu, Shanshan
Piao, Sichen
Shan, Zhongyan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The purpose of the present study was to investigate serum trace elements in Graves’ disease (GD) patients with or without orbitopathy in Northeast China.
Methods.
Patients with newly diagnosed Graves’ disease (HyGD) (n=66), GD patients with euthyroid status or subclinical thyroidism after treatment (EUGD) (n=55), GO patients with euthyroid status or subclinical thyroidism after treatment (GO) (n=57), and normal controls (NC) (n=66) were enrolled in this study.
Serum trace elements were measured with ICP-MS.
Results.
Serum selenium (Se) levels in EUGD group (median: 7.53 µg/dL), HyGD group (median: 6.76 µg/dL), and GO group (median: 7.40 µg/dL) were significantly lower than those in NC group (median: 9.20 µg/dL, all P<0.01).
Serum copper (Cu) levels in GO group (median: 95.93 µg/dL) were significantly lower than those in the NC group (median: 113.59 µg/dL, P=0.015).
After being adjusted for multivariables, thyroid-specific antibodies grade was associated with low Se levels.
Hyperthyroidism and thyroid-specific antibodies grade were associated with high Cu levels.
In addition, orbitopathy was associated with low Cu levels.
Conclusions.
Thyroid autoimmunity was associated with low Se levels.
Hyperthyroidism and thyroid autoimmunity may be associated with relatively high serum Cu levels.
Alternatively, ophthalmopathy may be related to low serum Cu levels.
American Psychological Association (APA)
Liu, Yongping& Liu, Shanshan& Mao, Jinyuan& Piao, Sichen& Qin, Jing& Peng, Shiqiao…[et al.]. 2018. Serum Trace Elements Profile in Graves’ Disease Patients with or without Orbitopathy in Northeast China. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125573
Modern Language Association (MLA)
Liu, Yongping…[et al.]. Serum Trace Elements Profile in Graves’ Disease Patients with or without Orbitopathy in Northeast China. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1125573
American Medical Association (AMA)
Liu, Yongping& Liu, Shanshan& Mao, Jinyuan& Piao, Sichen& Qin, Jing& Peng, Shiqiao…[et al.]. Serum Trace Elements Profile in Graves’ Disease Patients with or without Orbitopathy in Northeast China. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125573