Synthesis and Characterization of Polycaprolactone-Based Polyurethanes for the Fabrication of Elastic Guided Bone Regeneration Membrane
Joint Authors
Lee, Shyh-Yuan
Wu, Sheng-Chien
Chen, Hsuan
Tsai, Lo-Lin
Tzeng, Jy-Jiunn
Lin, Yuan-Min
Lin, Chih-Hsin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The aim of this research is to synthesize polycaprolactone-based polyurethanes (PCL-based PUs) that can be further used for the fabrication of guided bone regeneration (GBR) membranes with higher tensile strength and elongation at break than collagen and PTFE membranes.
The PCL-based PUs were prepared by the polymerization of polycaprolactone (PCL) diol with 1,6-hexamethylene diisocyanate (HDI) at different ratios using either polyethylene glycol (PEG) or ethylenediamine (EDA) as chain extenders.
The chemical, mechanical, and thermal properties of the synthesized polymers were determined using NMR, FTIR, GPC, DSC, and tensile tester.
The PCL and polyurethanes were fabricated as nanofiber membranes by electrospinning, and their mechanical properties and SEM morphology were also investigated.
In vitro tests, including WST-1 assay, SEM of cells, and phalloidin cytoskeleton staining, were also performed.
It was shown that electrospun membranes made of PCL and PCL-HDI-PEG (2 : 3 : 1) possessed tensile strength of 19.84 MPa and 11.72 MPa and elongation at break of 627% and 362%, respectively.
These numbers are equivalent or higher than most of the commercially available collagen and PTFE membrane.
As a result, these membranes may have potential for future GBR applications.
American Psychological Association (APA)
Lee, Shyh-Yuan& Wu, Sheng-Chien& Chen, Hsuan& Tsai, Lo-Lin& Tzeng, Jy-Jiunn& Lin, Chih-Hsin…[et al.]. 2018. Synthesis and Characterization of Polycaprolactone-Based Polyurethanes for the Fabrication of Elastic Guided Bone Regeneration Membrane. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1125721
Modern Language Association (MLA)
Lee, Shyh-Yuan…[et al.]. Synthesis and Characterization of Polycaprolactone-Based Polyurethanes for the Fabrication of Elastic Guided Bone Regeneration Membrane. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1125721
American Medical Association (AMA)
Lee, Shyh-Yuan& Wu, Sheng-Chien& Chen, Hsuan& Tsai, Lo-Lin& Tzeng, Jy-Jiunn& Lin, Chih-Hsin…[et al.]. Synthesis and Characterization of Polycaprolactone-Based Polyurethanes for the Fabrication of Elastic Guided Bone Regeneration Membrane. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1125721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125721