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Immunoglobulin E and G Levels in Predicting Minimal Change Disease before Renal Biopsy
Joint Authors
Hsiao, Ching-Chung
Tu, Kun-Hua
Hsieh, Chun-Yih
Lee, Cheng-Chia
Chang, Chih-Hsiang
Fan, Pei-Chun
Tian, Ya-Chung
Fang, Ji-Tseng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
The diagnosis of minimal change disease in adults relies mainly on renal biopsy, but this procedure is not without complications.
Despite the advancements in technique of percutaneous renal biopsy, biopsy-related complications still occur.
Bleeding is one of the major complications, which may lead to hemodynamic instability and, sometimes, even death.
Thus, we developed a model to predict MCD for high-risk patients unsuitable for renal biopsy.
Methods.
We enrolled 142 patients with nephrotic syndrome who received renal biopsy between October 2007 and April 2011 at one tertiary medical center in this study.
Demographic, clinical, and prebiopsy laboratory variables were retrospectively recorded and analyzed.
Results.
The overall prevalence of MCD was 26.8%.
Age, hemoglobin levels, 24-hour urine protein, immunoglobulin (Ig) G, and IgE differed significantly between the MCD and non-MCD groups.
Logistic regression analysis showed a significant increase in the risk of developing MCD as the number of Ig risk factors, namely, IgG < 450 mg/dl and IgE > 110 mg/dl, increased.
Having both risk factors significantly increased the chances of receiving a diagnosis of MCD (by 31.84-fold, P =.007) compared with having neither.
Combining the aforementioned clinical model and the 2 Ig risk factors was the best in predicting the diagnosis of MCD, with the area under a receiver-operating characteristic curve of 0.91.
Conclusions.
Combining clinical model and this 2 Ig risk factors provides physicians simple and valuable clinical markers to diagnose MCD.
American Psychological Association (APA)
Hsiao, Ching-Chung& Tu, Kun-Hua& Hsieh, Chun-Yih& Lee, Cheng-Chia& Chang, Chih-Hsiang& Fan, Pei-Chun…[et al.]. 2018. Immunoglobulin E and G Levels in Predicting Minimal Change Disease before Renal Biopsy. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125844
Modern Language Association (MLA)
Hsiao, Ching-Chung…[et al.]. Immunoglobulin E and G Levels in Predicting Minimal Change Disease before Renal Biopsy. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1125844
American Medical Association (AMA)
Hsiao, Ching-Chung& Tu, Kun-Hua& Hsieh, Chun-Yih& Lee, Cheng-Chia& Chang, Chih-Hsiang& Fan, Pei-Chun…[et al.]. Immunoglobulin E and G Levels in Predicting Minimal Change Disease before Renal Biopsy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125844