Extracts from Myrtle Liqueur Processing Waste Modulate Stem Cells Pluripotency under Stressing Conditions
Joint Authors
Maioli, Margherita
Santaniello, Sara
Cruciani, Sara
Fadda, Angela
Sale, Luana
Sarais, Giorgia
Sanna, Daniele
Mulas, Maurizio
Ginesu, Giorgio Carlo
Cossu, Maria Laura
Serra, Pier Andrea
Ventura, Carlo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Nutraceuticals present in food are molecules able to exert biological activity for the prevention and treatment of various diseases, in form of pharmaceutical preparations, such as capsules, cream, or pills.
Myrtus communis L.
is a spontaneous Mediterranean evergreen shrub, widely known for the liqueur obtained from its berries rich in phytochemicals such as tannins and flavonoids.
In the present study, we aimed to evaluate the properties of myrtle byproducts, residual of the industrial liqueur processing, in Adipose-derived stem cells (ADSCs) induced at oxidative stress by in vitro H2O2 treatment.
Cells were exposed for 12-24 and 48h at treatment with extracts and then senescence-induced.
ROS production was then determined.
The real-time PCR was performed to evaluate the expression of inflammatory cytokines and sirtuin-dependent epigenetic changes, as well the modifications in terms of stem cell pluripotency.
The β-galactosidase assay was conducted to analyze stem cell senescence after treatment.
Our results show that industrial myrtle byproducts retain a high antioxidant and antisenescence activity, protecting cells from oxidative stress damages.
The results obtained suggest that residues from myrtle liqueur production could be used as resource in formulation of food supplements or pharmaceutical preparations with antioxidant, antiaging, and anti-inflammatory activity.
American Psychological Association (APA)
Cruciani, Sara& Santaniello, Sara& Fadda, Angela& Sale, Luana& Sarais, Giorgia& Sanna, Daniele…[et al.]. 2019. Extracts from Myrtle Liqueur Processing Waste Modulate Stem Cells Pluripotency under Stressing Conditions. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1126128
Modern Language Association (MLA)
Cruciani, Sara…[et al.]. Extracts from Myrtle Liqueur Processing Waste Modulate Stem Cells Pluripotency under Stressing Conditions. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1126128
American Medical Association (AMA)
Cruciani, Sara& Santaniello, Sara& Fadda, Angela& Sale, Luana& Sarais, Giorgia& Sanna, Daniele…[et al.]. Extracts from Myrtle Liqueur Processing Waste Modulate Stem Cells Pluripotency under Stressing Conditions. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1126128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126128