Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study
Joint Authors
Ji, Baolan
Zhang, Mei
Ban, Bo
Wang, Panpan
Shao, Qian
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS).
Methods.
A cross-sectional study of 91 Chinese children and adolescents with ISS was performed.
Anthropometric measurements and biochemical parameters were tested.
The standard deviation score of IGF-1 (IGF-1 SDS) was calculated.
Results.
A univariate analysis displayed a significant positive correlation between IGF-1 SDS and UA (P=0.004).
In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168 μmol/L and 301 μmol/L (β 0.010, 95% CI 0.004–0.017; P=0.002).
The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168 μmol/L (β −0.055, 95% CI −0.081–−0.028; P<0.001) or more than 301 μmol/L (β −0.005, 95% CI −0.013–0.002; P=0.174).
Conclusions.
This study demonstrated a nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS.
This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1, whereas appropriate UA levels have a beneficial effect.
American Psychological Association (APA)
Wang, Panpan& Ji, Baolan& Shao, Qian& Zhang, Mei& Ban, Bo. 2018. Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1126474
Modern Language Association (MLA)
Wang, Panpan…[et al.]. Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1126474
American Medical Association (AMA)
Wang, Panpan& Ji, Baolan& Shao, Qian& Zhang, Mei& Ban, Bo. Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1126474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126474