Fibrosis-4 Model Influences Results of Patients with Hepatocellular Carcinoma Undergoing Hepatectomy
Joint Authors
Wang, Haiqing
Liu, Aixiang
Bo, Wentao
Feng, Xielin
Hu, Yong
Tian, Lang
Zhang, Hui
Tang, Xiaoli
Zhang, Lixia
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Several noninvasive models based on routine laboratory index have been developed to predict liver fibrosis.
Our aim is to discuss whether these indexes could predict prognosis in patients with hepatocellular carcinoma undergoing hepatectomy.
Methods.
This study retrospectively enrolled 788 consecutive hepatocellular carcinoma patients undergoing liver resection in the cohort.
Univariate and multivariate analysis were used to identify the risk factors of complications, survival, and disease-free survival.
Results.
Fibrosis-4 index had the best prediction ability for cirrhosis among other noninvasive models.
Both the univariate and multivariate analyses showed that fibrosis-4 was independent risk factor for survival and disease-free survival.
With the optimal cutoff value of 3.15, patients with fibrosis-4 ⩾3.15 had higher postoperative hepatic insufficiency (P=0.006) and worse survival than the fibrosis-4<3.15 group.
The corresponding 1-year, 3-year, and 5-year overall survival were 80.9%, 56.3%, and 44.6% in the High fibrosis-4 group and were 86.5%, 69.9%, and 63.2% in the Low fibrosis-4 group, respectively (P<0.001).
Worse disease-free survival was also observed in the fibrosis-4 ⩾3.15 group; the corresponding 1-year, 3-year, and 5-year disease-free survival were 74.9%, 45.3%, and 24.6% for the fibrosis-4 ⩾3.15 group and were 81.8%, 54.9%, and 34.4% for the fibrosis-4<3.15 group (P=0.009).
Conclusions.
Fibrosis-4 is useful for assessing the short-term and long-term results for hepatocellular carcinoma patients with liver resection.
American Psychological Association (APA)
Wang, Haiqing& Liu, Aixiang& Bo, Wentao& Feng, Xielin& Hu, Yong& Tian, Lang…[et al.]. 2018. Fibrosis-4 Model Influences Results of Patients with Hepatocellular Carcinoma Undergoing Hepatectomy. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126522
Modern Language Association (MLA)
Wang, Haiqing…[et al.]. Fibrosis-4 Model Influences Results of Patients with Hepatocellular Carcinoma Undergoing Hepatectomy. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126522
American Medical Association (AMA)
Wang, Haiqing& Liu, Aixiang& Bo, Wentao& Feng, Xielin& Hu, Yong& Tian, Lang…[et al.]. Fibrosis-4 Model Influences Results of Patients with Hepatocellular Carcinoma Undergoing Hepatectomy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126522