An Approach to Identify Individual Functional Single Nucleotide Polymorphisms and Isoform MicroRNAs

Joint Authors

Wang, Ying
Ru, Jidong
Jin, Tao
Sun, Ming
Jia, Lizhu
Sun, Guijiang

Source

BioMed Research International

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-07-30

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

MicroRNAs (miRNAs) and single nucleotide polymorphisms (SNPs) play important roles in disease risk and development, especially cancer.

Importantly, when SNPs are located in pre-miRNAs, they affect their splicing mechanism and change the function of miRNAs.

To improve disease risk assessment, we propose an approach and developed a software tool, IsomiR_Find, to identify disease/phenotype-related SNPs and isomiRs in individuals.

Our approach is based on the individual’s samples, with SNP information extracted from the 1000 Genomes Project.

SNPs were mapped to pre-miRNAs based on whole-genome coordinates and then SNP-pre-miRNA sequences were constructed.

Moreover, we developed matpred2, a software tool to identify the four splicing sites of mature miRNAs.

Using matpred2, we identified isomiRs and then verified them by searching within individual miRNA sequencing data.

Our approach yielded biomarkers for biological experiments, mined functions of miRNAs and SNPs, improved disease risk assessment, and provided a way to achieve individualized precision medicine.

American Psychological Association (APA)

Wang, Ying & Ru, Jidong& Jin, Tao& Sun, Ming& Jia, Lizhu& Sun, Guijiang. 2019. An Approach to Identify Individual Functional Single Nucleotide Polymorphisms and Isoform MicroRNAs. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1126531

Modern Language Association (MLA)

Wang, Ying…[et al.]. An Approach to Identify Individual Functional Single Nucleotide Polymorphisms and Isoform MicroRNAs. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1126531

American Medical Association (AMA)

Wang, Ying & Ru, Jidong& Jin, Tao& Sun, Ming& Jia, Lizhu& Sun, Guijiang. An Approach to Identify Individual Functional Single Nucleotide Polymorphisms and Isoform MicroRNAs. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1126531

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1126531