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Precision Medicine in Targeted Therapies for Severe Asthma: Is There Any Place for “Omics” Technology?
Joint Authors
Galeone, Carla
Facciolongo, Nicola
Scelfo, Chiara
Bertolini, Francesca
Caminati, Marco
Ruggiero, Patrizia
Menzella, Francesco
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-11
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
According to the current guidelines, severe asthma still represents a controversial topic in terms of definition and management.
The introduction of novel biological therapies as a treatment option for severe asthmatic patients paved the way to a personalized approach, which aims at matching the appropriate therapy with the different asthma phenotypes.
Traditional asthma phenotypes have been decomposing by an increasing number of asthma subclasses based on functional and physiopathological mechanisms.
This is possible thanks to the development and application of different omics technologies.
The new asthma classification patterns, particularly concerning severe asthma, include an increasing number of endotypes that have been identified using new omics technologies.
The identification of endotypes provides new opportunities for the management of asthma symptoms, but this implies that biological therapies which target inflammatory mediators in the frame of specific patterns of inflammation should be developed.
However, the pathway leading to a precision approach in asthma treatment is still at its beginning.
The aim of this review is providing a synthetic overview of the current asthma management, with a particular focus on severe asthma, in the light of phenotype and endotype approach, and summarizing the current knowledge about “omics” science and their therapeutic relevance in the field of bronchial asthma.
American Psychological Association (APA)
Galeone, Carla& Scelfo, Chiara& Bertolini, Francesca& Caminati, Marco& Ruggiero, Patrizia& Facciolongo, Nicola…[et al.]. 2018. Precision Medicine in Targeted Therapies for Severe Asthma: Is There Any Place for “Omics” Technology?. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1126809
Modern Language Association (MLA)
Galeone, Carla…[et al.]. Precision Medicine in Targeted Therapies for Severe Asthma: Is There Any Place for “Omics” Technology?. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1126809
American Medical Association (AMA)
Galeone, Carla& Scelfo, Chiara& Bertolini, Francesca& Caminati, Marco& Ruggiero, Patrizia& Facciolongo, Nicola…[et al.]. Precision Medicine in Targeted Therapies for Severe Asthma: Is There Any Place for “Omics” Technology?. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1126809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126809