Potassium Channel Activation Is Involved in the Cardiovascular Effects Induced by Freeze Dried Syzygium jambolanum (Lam.) DC Fruit Juice
Joint Authors
Medeiros, Isac Almeida de
Assis, Kívia S.
Araújo, Islania G. A.
de Azevedo, Fátima de L. A. A.
Maciel, Priscilla M. P.
Machado Calzerra, Natália T.
da Silva, Tays A. F.
Assis, Valéria L.
de Vasconcelos, Aliny P.
Santos, Carlos A. G.
Meireles, Bruno R. L. A.
Cordeiro, Angela M. T. M.
Araújo, Demetrius A. M.
Ribeiro, Thais P.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This work aimed to explore the cardiovascular effects induced by freeze-dried juice from Syzygium jambolanum (Lam.) DC fruits (JSJ).
JSJ presented high polyphenol content and steroids.
HPLC analysis revealed that 2,5-dihydroxybenzoic and caffeic acid were present in higher amounts in the JSJ extract.
In rat, JSJ induces hypotension and vasodilatation in mesenteric arteries, with or without vascular endothelium.
JSJ-mediated vasodilation response against contractions induced with KCl (60 mM) depolarizing solution was significantly lower than the responses induced by JSJ when evaluated against phenylephrine-induced contractions.
To investigate the involvement of potassium channels we used Tyrode’s solution with KCl (20 mM) or tetraethylammonium (1.0, 3.0, or 5.0 mM).
In these conditions JSJ-induced effects were significantly attenuated.
To investigate the potassium channel subtypes involved in the response, we used 4-aminopyridine, glibenclamide, BaCl2, and iberiotoxin.
In the presence (simultaneous) of different potassium channel blockers we observed a significant attenuation of JSJ-induced effect.
Inhibition was also observed when using BaCl2, glibenclamide, or 4-aminopyridine, separately.
However, incubation with iberiotoxin did not promote changes in either maximum effect, or potency.
We also evidenced a discrete participation of CaV channels in the JSJ-induced vasorelaxant effect.
In addition, patch-clamp studies demonstrated that JSJ could activate potassium channels.
In conclusion, JSJ promotes hypotension and vasorelaxation in rats, involving, at least, the activation of potassium channels.
American Psychological Association (APA)
Assis, Kívia S.& Araújo, Islania G. A.& de Azevedo, Fátima de L. A. A.& Maciel, Priscilla M. P.& Machado Calzerra, Natália T.& da Silva, Tays A. F.…[et al.]. 2018. Potassium Channel Activation Is Involved in the Cardiovascular Effects Induced by Freeze Dried Syzygium jambolanum (Lam.) DC Fruit Juice. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1126930
Modern Language Association (MLA)
Assis, Kívia S.…[et al.]. Potassium Channel Activation Is Involved in the Cardiovascular Effects Induced by Freeze Dried Syzygium jambolanum (Lam.) DC Fruit Juice. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1126930
American Medical Association (AMA)
Assis, Kívia S.& Araújo, Islania G. A.& de Azevedo, Fátima de L. A. A.& Maciel, Priscilla M. P.& Machado Calzerra, Natália T.& da Silva, Tays A. F.…[et al.]. Potassium Channel Activation Is Involved in the Cardiovascular Effects Induced by Freeze Dried Syzygium jambolanum (Lam.) DC Fruit Juice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1126930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126930