The Signaling Pathways Involved in the Antiatherosclerotic Effects Produced by Chinese Herbal Medicines
Joint Authors
Lu, Li
Sun, Xiaodong
Qin, Yating
Guo, Xiaomei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-13
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Cardiovascular diseases (CVDs) are considered to be the predominant cause of death in the world.
Chinese herb medicines (CHMs) have been widely used for the treatment of CVDs in Asian countries for thousands of years.
One reason of high efficacy of CHMs in treating CVDs is attributed to their inhibition in atherosclerosis (AS) development, a critical contributor to CVDs occurrence.
Cumulative studies have demonstrated that CHMs alleviate atherogenesis via mediating pathophysiologic events involved in AS.
However, there is deficiency in the summaries regarding antiatherogenic signal pathways regulated by CHMs.
In this review, we focus on the signal cascades by which herb medicines and relevant extractives, derivatives, and patents improve proatherogenic processes including endothelium dysfunction, lipid accumulation, and inflammation.
We mainly elaborate the CHMs-mediated signaling pathways in endothelial cells, macrophages, and vascular smooth muscle cells of each pathogenic event.
Moreover, we briefly describe the other AS-related factors such as thrombosis, autophagy, immune response, and noncoding RNAs and effects of CHMs on them in the way of cascade regulation, which is helpful to further illustrate the molecular mechanisms of AS initiation and progression and discover newly effective agents for AS management.
American Psychological Association (APA)
Lu, Li& Sun, Xiaodong& Qin, Yating& Guo, Xiaomei. 2018. The Signaling Pathways Involved in the Antiatherosclerotic Effects Produced by Chinese Herbal Medicines. BioMed Research International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1127260
Modern Language Association (MLA)
Lu, Li…[et al.]. The Signaling Pathways Involved in the Antiatherosclerotic Effects Produced by Chinese Herbal Medicines. BioMed Research International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1127260
American Medical Association (AMA)
Lu, Li& Sun, Xiaodong& Qin, Yating& Guo, Xiaomei. The Signaling Pathways Involved in the Antiatherosclerotic Effects Produced by Chinese Herbal Medicines. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1127260
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127260