Combined Optimized Effect of a Highly Self-Organized Nanosubstrate and an Electric Field on Osteoblast Bone Cells Activity
Joint Authors
Deligianni, Despina
Kostopoulos, V.
Portan, Diana V.
Papanicolaou, George C.
Psarras, Georgios C.
Tyllianakis, Minos
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The effect of an electric field within specific intensity limits on the activity of human cells has been previously investigated.
However, there are a considerable number of factors that influence the in vitro development of cell populations.
In biocompatibility studies, the nature of the substrate and its topography are decisive in osteoblasts bone cells development.
Further on, electrical field stimulation may activate biochemical paths that contribute to a faster, more effective self-adjustment and proliferation of specific cell types on various nanosubstrates.
Within the present research, an electrical stimulation device has been manufactured and optimum values of parameters that led to enhanced osteoblasts activity, with respect to the alkaline phosphatase and total protein levels, have been found.
Homogeneous electric field distribution induced by a highly organized titanium dioxide nanotubes substrate had an optimum effect on cell response.
Specific substrate topography in combination with appropriate electrical stimulation enhanced osteoblasts bone cells capacity to self-adjust the levels of their specific biomarkers.
The findings are of importance in the future design and development of new advanced orthopaedic materials for hard tissue replacement.
American Psychological Association (APA)
Portan, Diana V.& Deligianni, Despina& Papanicolaou, George C.& Kostopoulos, V.& Psarras, Georgios C.& Tyllianakis, Minos. 2019. Combined Optimized Effect of a Highly Self-Organized Nanosubstrate and an Electric Field on Osteoblast Bone Cells Activity. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1127397
Modern Language Association (MLA)
Portan, Diana V.…[et al.]. Combined Optimized Effect of a Highly Self-Organized Nanosubstrate and an Electric Field on Osteoblast Bone Cells Activity. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1127397
American Medical Association (AMA)
Portan, Diana V.& Deligianni, Despina& Papanicolaou, George C.& Kostopoulos, V.& Psarras, Georgios C.& Tyllianakis, Minos. Combined Optimized Effect of a Highly Self-Organized Nanosubstrate and an Electric Field on Osteoblast Bone Cells Activity. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1127397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127397