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Frequency of Hepatobiliary Manifestations and Concomitant Liver Disease in Inflammatory Bowel Disease Patients
Joint Authors
Lyra, Andre Castro
Santana, Genoile Oliveira
Silva, Juliana
Brito, Beatriz S.
Silva, Isaac Neri de N.
Nóbrega, Viviane G.
Silva, Maria Carolina S. M. da
Gomes, Hemerson Dyego de N.
Fortes, Flora Maria
Pimentel, Andrea M.
Mota, Jaciane
Almeida, Neogélia
Surlo, Valdiana C.
Rocha, Raquel
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
In inflammatory bowel disease (IBD) patients there are reports of the occurrence of hepatobiliary manifestations, so the aim of this study was to evaluate the hepatobiliary manifestations in patients with Crohn’s disease (CD) and ulcerative colitis (UC) from an IBD reference center.
Methods.
Cross-sectional study in an IBD reference center, with interviews and review of medical charts, between July 2015 and August 2016.
A questionnaire addressing epidemiological and clinical characteristics was used.
Results.
We interviewed 306 patients, and the majority had UC (53.9%) and were female (61.8%).
Hepatobiliary manifestations were observed in 60 (19.6%) patients with IBD.
In the greater part of the patients (56.7%) hepatobiliary disorders were detected after the diagnosis of IBD.
In UC (18.2%) patients, the hepatobiliary disorders identified were 11 (6.7%) non-alcoholic fatty liver disease, 9 (5.5%) cholelithiasis, 6 (3.6%) primary sclerosing cholangitis (PSC), 3 (1.8%) hepatotoxicity associated with azathioprine, 1 (0.6%) hepatitis B, and 1 (0.6%) hepatic fibrosis.
In CD (21.3%) patients, 11 (7.8%) had cholelithiasis, 11 (7.8%) non-alcoholic fatty liver disease, 4 (2.8%) PSC, 3 (2.1%) hepatotoxicity, 1 (0.7%) hepatitis B, (0.7%) hepatitis C, 1 (0.7%) alcoholic liver disease, and 1 (0.7%) autoimmune hepatitis (AIH).
There was one case of PSC/AIH overlap syndrome.
Conclusion.
The frequency of hepatobiliary disorders was similar in both forms of IBD in patients evaluated.
The most common nonspecific hepatobiliary manifestations in IBD patients were non-alcoholic liver disease and cholelithiasis.
The most common specific hepatobiliary disorder was PSC in patients with extensive UC or ileocolonic CD involvement; this was seen more frequently in male patients.
American Psychological Association (APA)
Silva, Juliana& Brito, Beatriz S.& Silva, Isaac Neri de N.& Nóbrega, Viviane G.& Silva, Maria Carolina S. M. da& Gomes, Hemerson Dyego de N.…[et al.]. 2019. Frequency of Hepatobiliary Manifestations and Concomitant Liver Disease in Inflammatory Bowel Disease Patients. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1127444
Modern Language Association (MLA)
Silva, Juliana…[et al.]. Frequency of Hepatobiliary Manifestations and Concomitant Liver Disease in Inflammatory Bowel Disease Patients. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1127444
American Medical Association (AMA)
Silva, Juliana& Brito, Beatriz S.& Silva, Isaac Neri de N.& Nóbrega, Viviane G.& Silva, Maria Carolina S. M. da& Gomes, Hemerson Dyego de N.…[et al.]. Frequency of Hepatobiliary Manifestations and Concomitant Liver Disease in Inflammatory Bowel Disease Patients. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1127444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127444