The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis
Joint Authors
Zhou, Zonglei
Zhou, Ruzhen
Li, Kunpeng
Wei, Wen
Zhang, Zengqiao
Zhu, Yan
Luan, Rongsheng
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Several studies have investigated the association between Toxoplasma gondii (T.
gondii) infection and risk of Parkinson’s disease (PD) with inconsistent results.
Clarifying this relation might be useful for better understanding of the risk factors and the relevant mechanisms of PD, thus a meta-analysis was conducted to explore whether exposure to T.
gondii is associated with an increased risk of PD.
Methods.
We conducted this meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
A rigorous literature selection was performed by using the databases of PubMed, Embase, Web of Science, Cochrane Library, and ScienceDirect.
Odds ratio (OR) and corresponding 95% confidential interval (CI) were pooled by using fixed-effects models.
Sensitivity analysis, publication bias test, and methodological quality assessment of studies were also performed.
Results.
Seven studies involving 1086 subjects were included in this meta-analysis.
Pooled data by using fixed-effects models suggested both latent infection (OR, 1.17; 95% CI, 0.86 to 1.58; P=0.314) and acute infection (OR, 1.13; 95% CI, 0.30 to 4.35; P=0.855) were not associated with PD risk.
Stable and robust estimates were confirmed by sensitivity analysis.
No publication bias was found by visual inspection of the funnel plot, Begg’s, and Egger’s test.
Conclusions.
This meta-analysis does not support any possible association between T.
gondii infection and risk of PD.
Researches are still warranted to further explore the underlying mechanisms of T.
gondii in the pathogenesis of PD and their causal relationship.
American Psychological Association (APA)
Zhou, Zonglei& Zhou, Ruzhen& Li, Kunpeng& Wei, Wen& Zhang, Zengqiao& Zhu, Yan…[et al.]. 2019. The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1127772
Modern Language Association (MLA)
Zhou, Zonglei…[et al.]. The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1127772
American Medical Association (AMA)
Zhou, Zonglei& Zhou, Ruzhen& Li, Kunpeng& Wei, Wen& Zhang, Zengqiao& Zhu, Yan…[et al.]. The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1127772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127772