Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions
Joint Authors
Wattanathorn, Jintanaporn
Prabsattroo, Thawatchai
Somsapt, Pichet
Sritragool, Opass
Muchimapura, Supaporn
Thukham-mee, Wipawee
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In this study, we aimed to assess the effect and possible underlying mechanism of Anacardium occidentale leaves extract on male sexual behaviors in stress-exposed rats.
Male Wistar rats were orally given A.
occidentale extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days.
Sexual behaviors, serum testosterone and corticosterone levels, TH-positive cells density in nucleus accumbens (NAc) and ventral tegmental area (VTA), MAO-B activity in NAc and medial preoptic area (MPOA), testis histology together with phosphodiesterase type-5 ( PDE-5) activity, and endothelial nitric oxide synthase (eNOS) expression in penis were evaluated after treatment.
All doses of extract improved male sexual behaviors, suppressed MAO-B in NAc, enhanced TH-positive cells density in NAc, suppressed PDE-5 in penis, and enhanced interstitial cell of Leydig.
The increase of serum testosterone, TH-positive cells density in VTA, eNOS expression in penis, and the decreased serum corticosterone were observed at some doses.
Therefore, the sexual enhancing effect of extract occurred mainly via the improved dopaminergic and testicular functions.
PDE-5 suppression in penis also played the role especially in the increased intromission behavior.
Therefore, A.
occidentale leaves extract is the potential protective agent against sexual dysfunction.
However, further researches are necessary.
American Psychological Association (APA)
Wattanathorn, Jintanaporn& Prabsattroo, Thawatchai& Somsapt, Pichet& Sritragool, Opass& Thukham-mee, Wipawee& Muchimapura, Supaporn. 2018. Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1127937
Modern Language Association (MLA)
Wattanathorn, Jintanaporn…[et al.]. Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1127937
American Medical Association (AMA)
Wattanathorn, Jintanaporn& Prabsattroo, Thawatchai& Somsapt, Pichet& Sritragool, Opass& Thukham-mee, Wipawee& Muchimapura, Supaporn. Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1127937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127937