The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment
Joint Authors
Yan, Zhiqiang
Li, Qiushuang
Xiong, Yang
Ji, Conghua
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-13
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Antitumor therapy using a combination of drugs has shown increased clinical efficacy.
Active constituents derived from plants can offer several advantages, such as high efficiacy, low toxicity, extensive effects, and multiple targets.
At present, the combination of plants’ active constituents and chemotherapeutic drugs has attracted increased attention.
Nanodrug delivery systems (NDDSs) have been widely used in tumor-targeted therapy because of their efficacy of delivering antitumor drugs.
The in vivo process of tumor-targeted NDDSs has several steps.
They include blood circulation, tumor accumulation and penetration, target cell internalization and uptake, and drug release and drug response.
In each step, NDDSs encounter multiple barriers that prevent their effective delivery to target sites.
Studies have been performed to find alternative strategies to overcome these barriers.
We reviewed the recent progress of codelivery of active constituents of plants and chemotherapeutics using NDDSs.
Progress into transversing the physiological barriers for more effective in vivo antitumor delivery will be discussed in this review.
American Psychological Association (APA)
Li, Qiushuang& Xiong, Yang& Ji, Conghua& Yan, Zhiqiang. 2019. The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment. BioMed Research International،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1128304
Modern Language Association (MLA)
Li, Qiushuang…[et al.]. The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment. BioMed Research International No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1128304
American Medical Association (AMA)
Li, Qiushuang& Xiong, Yang& Ji, Conghua& Yan, Zhiqiang. The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1128304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128304