Fertility Drugs Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis
Joint Authors
Jiang, Hongchi
Yu, QingAn
Liu, KunPeng
Ma, DaKun
Wu, YaoHua
Dai, WenJie
Lv, XiaoYing
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Associations have been demonstrated between fertility drugs and a variety of hormone-sensitive carcinomas.
The purpose of this study was to determine the relationship between fertility drugs used in the treatment of female infertility and the risk of thyroid cancer.
To investigate the clinical significance of fertility drugs used for the treatment of female infertility and the risk associated with thyroid cancer, we performed a literature search using PubMed, MEDLINE, the Cochrane Library, the Web of Science, and EBSCOHOST for comparative studies published any time prior to July 21, 2017.
The studies included women who were treated for infertility with fertility drugs, such as clomiphene citrate, gonadotropins, or other unspecified fertility agents, which reported the incidence of thyroid cancer as the main outcome.
Eight studies were included in the meta-analyses.
Among women with infertility, there was a significant positive association between thyroid cancer risk and the use of fertility drugs (relative risk [RR] = 1.35; 95% confidence interval [CI] 1.12–1.64; P=0.002).
Additionally, among women with infertility, the use of clomiphene citrate was associated with an increased risk of thyroid cancer compared to women who did not use fertility drugs (RR = 1.45; 95% CI 1.12–1.88; P=0.005).
After pooling results, we found that the parity status of infertile women using fertility drugs was not associated with thyroid cancer risk (RR = 0.99; 95% CI 0.61–1.58, P=0.95).
In summary, clomiphene citrate (the most commonly used fertility drug) and other fertility drugs are associated with an increased risk of thyroid cancer.
American Psychological Association (APA)
Yu, QingAn& Lv, XiaoYing& Liu, KunPeng& Ma, DaKun& Wu, YaoHua& Dai, WenJie…[et al.]. 2018. Fertility Drugs Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128318
Modern Language Association (MLA)
Yu, QingAn…[et al.]. Fertility Drugs Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1128318
American Medical Association (AMA)
Yu, QingAn& Lv, XiaoYing& Liu, KunPeng& Ma, DaKun& Wu, YaoHua& Dai, WenJie…[et al.]. Fertility Drugs Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128318