Spermatogenesis Abnormalities following Hormonal Therapy in Transwomen
Joint Authors
Selvaggi, Gennaro
Jindarak, Sirachai
Angspatt, Apichai
Pungrasmi, Pornthep
Suwajo, Poonpismai
Tiewtranon, Preecha
Nilprapha, Kasama
Atikankul, Taywin
Iamphongsai, Seree
Promniyom, Pasu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
To measure spermatogenesis abnormalities in transwomen at the time of sex reassignment surgery (SRS) and to analyze the association between hormonal therapy duration and infertility severity.
Design.
Retrospective study.
Setting.
University hospital.
Patients.
One-hundred seventy-three transwomen who underwent SRS from January 2000 to December 2015.
Interventions.
All orchidectomy specimens were retrospectively reviewed and classified.
History of hormonal therapy duration was retrieved from medical records.
Main Outcome Measures.
Histological examinations of orchidectomy specimens were performed to assess spermatogenesis.
Results.
One-hundred seventy-three orchidectomy specimens were evaluated.
Histological examinations showed maturation arrest in 36.4%, hypospermatogenesis in 26%, Sertoli cell-only syndrome in 20.2%, normal spermatogenesis in 11%, and seminiferous tubule hyalinization in 6.4% of the specimens.
Spermatogenesis abnormality severity was not associated with the total therapy duration (P=0.81) or patient age at the time of surgery (P=0.88).
Testicular volumes and sizes were associated with spermatogenesis abnormality severity (P=0.001 and P=0.026, right testicle and left testicle, resp.).
Conclusion(s).
Feminizing hormonal treatment leads to reductions in testicular germ cell levels.
All transwomen should be warned about this consequence, and gamete preservation should be offered before starting hormonal treatment.
American Psychological Association (APA)
Jindarak, Sirachai& Nilprapha, Kasama& Atikankul, Taywin& Angspatt, Apichai& Pungrasmi, Pornthep& Iamphongsai, Seree…[et al.]. 2018. Spermatogenesis Abnormalities following Hormonal Therapy in Transwomen. BioMed Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1128785
Modern Language Association (MLA)
Jindarak, Sirachai…[et al.]. Spermatogenesis Abnormalities following Hormonal Therapy in Transwomen. BioMed Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1128785
American Medical Association (AMA)
Jindarak, Sirachai& Nilprapha, Kasama& Atikankul, Taywin& Angspatt, Apichai& Pungrasmi, Pornthep& Iamphongsai, Seree…[et al.]. Spermatogenesis Abnormalities following Hormonal Therapy in Transwomen. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1128785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128785