The Effect of Vitamin E and Metallothionein on the Antioxidant Capacities of Cadmium-Damaged Liver in Grass Carp Ctenopharyngodon idellus
Joint Authors
Ou, Yangping
Geng, Yi
Feng, Yang
Huang, Xiaoli
Duan, Yajiao
Fan, Wei
Duan, Jing
Wang, Kaiyu
Deng, Yongqiang
Chen, Defang
Yang, Shiyong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cadmium (Cd) causes a broad spectrum of toxicological effects to animals.
Aquatic animals were more likely to accumulate Cd than terrestrial animals because of the living environment.
Clearance of Cd in aquatic animals has become an important part of aquatic food safety.
The present study was focused on the oxidative damage induced by Cd in the liver of grass carp Ctenopharyngodon idellus and the protective effect of vitamin E (VE) and metallothionein (MT).
Grass carp were divided into four groups: the control group, Cd+phosphate-buffered saline (PBS) group, Cd+VE group, and Cd+MT group.
All fish were injected with CdCl2 on the first day and then VE, MT, and PBS were given 4 days after injection, respectively.
The liver function and antioxidant capacity of grass carp were evaluated.
Cd administration resulted in damage of liver function and morphology in liver, which was expressed as the increased content of AST and ALT, rupture of organelles, and decrease of CAT, SOD, and GSH-Px activity.
However, VE and MT treatments protected against Cd-induced damage of liver in grass carp by decreasing AST and ALT content, repairing organelles, and maintained the antioxidant system by elevating CAT, SOD, and GSH-Px activity and regulating related mRNA transcript expression.
The results revealed that VE and MT might play an important role in the treatment of heavy metal poisoning through their antioxidative effects.
American Psychological Association (APA)
Feng, Yang& Huang, Xiaoli& Duan, Yajiao& Fan, Wei& Duan, Jing& Wang, Kaiyu…[et al.]. 2018. The Effect of Vitamin E and Metallothionein on the Antioxidant Capacities of Cadmium-Damaged Liver in Grass Carp Ctenopharyngodon idellus. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128795
Modern Language Association (MLA)
Feng, Yang…[et al.]. The Effect of Vitamin E and Metallothionein on the Antioxidant Capacities of Cadmium-Damaged Liver in Grass Carp Ctenopharyngodon idellus. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128795
American Medical Association (AMA)
Feng, Yang& Huang, Xiaoli& Duan, Yajiao& Fan, Wei& Duan, Jing& Wang, Kaiyu…[et al.]. The Effect of Vitamin E and Metallothionein on the Antioxidant Capacities of Cadmium-Damaged Liver in Grass Carp Ctenopharyngodon idellus. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128795