Contribution of Levosimendan in Weaning from Mechanical Ventilation in Patients with Left Ventricular Dysfunction: A Pilot Study
Joint Authors
Routsi, C.
Nanas, S.
Tzanis, Georgios
Angelopoulos, Epameinondas
Kaltsi, Ifigeneia
Sideris, Antonios
Tyrovolas, Konstantinos
Kokkoris, Stelios
Gratziou, Christina
Source
Critical Care Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
Mechanically ventilated patients with left ventricular (LV) dysfunction are at risk of weaning failure.
We hypothesized that optimization of cardiovascular function might facilitate the weaning process.
Therefore, we investigated the efficacy of levosimendan in difficult-to-wean patients with impaired LV performance.
Materials and Methods.
Nineteen mechanically ventilated patients, with LV ejection fraction (LVEF) 34 ± 8%, difficult-to-wean from the ventilator, were assessed by transthoracic echocardiography before the start and at the end of a spontaneous breathing trial (SBT) (first SBT).
Eight patients successfully weaned.
The remaining 11 failed-to-wean patients received a 24-hour infusion of levosimendan, and they were reassessed during a second SBT.
Results.
After levosimendan administration, LVEF increased from 30 ± 10 to 36 ± 3% (p=0.01).
End-SBT peak e′ velocity increased from 7 to 9 cm/s (p=0.02).
E/e′ increased from 10.5 to 12.9 during the first SBT, whereas it remained constant at 10 throughout the second SBT (p=0.01).
During the second SBT, partial pressure of arterial oxygen and central venous oxygen saturation improved, compared to the first one (93 ± 34 vs.
67 ± 28 mmHg, p=0.03, and 66 ± 11% vs.
57 ± 9%, p=0.02, respectively).
Nine of the 11 patients were successfully weaned from the ventilator.
Conclusions.
In difficult-to-wean from mechanical ventilation patients with LV dysfunction, levosimendan might contribute to successful weaning by improving both systolic and diastolic LV function.
American Psychological Association (APA)
Kaltsi, Ifigeneia& Angelopoulos, Epameinondas& Tzanis, Georgios& Sideris, Antonios& Tyrovolas, Konstantinos& Kokkoris, Stelios…[et al.]. 2019. Contribution of Levosimendan in Weaning from Mechanical Ventilation in Patients with Left Ventricular Dysfunction: A Pilot Study. Critical Care Research and Practice،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1129123
Modern Language Association (MLA)
Kaltsi, Ifigeneia…[et al.]. Contribution of Levosimendan in Weaning from Mechanical Ventilation in Patients with Left Ventricular Dysfunction: A Pilot Study. Critical Care Research and Practice No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1129123
American Medical Association (AMA)
Kaltsi, Ifigeneia& Angelopoulos, Epameinondas& Tzanis, Georgios& Sideris, Antonios& Tyrovolas, Konstantinos& Kokkoris, Stelios…[et al.]. Contribution of Levosimendan in Weaning from Mechanical Ventilation in Patients with Left Ventricular Dysfunction: A Pilot Study. Critical Care Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1129123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129123