A Comparison of the Immunostimulatory Effects of Polysaccharides from Tetraploid and Diploid Echinacea purpurea
Joint Authors
Yang, Guang
Li, Keke
Liu, Cui
Peng, Peipei
Bai, Mei
Sun, Jiaqi
Li, Qingling
Yang, Zhuohong
Yang, Yue-Sheng
Wu, Hong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Polyploidization is an effective means of improving the active components and quality of secondary metabolism in medicinal plants.
In the present study, we compared the immunostimulatory effects of crude polysaccharides from tetraploid and diploid Echinacea purpurea.
The results showed that the carbohydrate contents of crude polysaccharide of tetraploid E.
purpurea (CPE4) and diploid E.
purpurea (CPE2) were 85.51% and 44.65%, respectively.
1H-nuclear magnetic resonance (NMR) spectroscopy and gel-permeation chromatography (GPC) analyses showed no major differences in the overall structure and molecular weight of polysaccharides between CPE4 and CPE2.
However, some differences in the relative content of the same polysaccharides group were observed between CPE4 and CPE2.
In in vitro tests, EP4 could stimulate lymphocyte proliferation and secretion of cytokines maximally at the concentration of 0.0312 mg/mL, and EP2 could stimulate lymphocyte proliferation and secretion of cytokines maximally at the concentration of 0.125 mg/mL.
In in vivo tests, EP4 was more effective at promoting the proliferation of lymphocytes and secretion of cytokines in mice immunosuppressed by cyclophosphamide than EP2 at the same concentration.
Taken together, these data demonstrated that the relative content of the partial polysaccharides group is increased, and the immunoregulatory effect is enhanced in tetraploid E.
purpurea.
American Psychological Association (APA)
Yang, Guang& Li, Keke& Liu, Cui& Peng, Peipei& Bai, Mei& Sun, Jiaqi…[et al.]. 2018. A Comparison of the Immunostimulatory Effects of Polysaccharides from Tetraploid and Diploid Echinacea purpurea. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1129255
Modern Language Association (MLA)
Yang, Guang…[et al.]. A Comparison of the Immunostimulatory Effects of Polysaccharides from Tetraploid and Diploid Echinacea purpurea. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1129255
American Medical Association (AMA)
Yang, Guang& Li, Keke& Liu, Cui& Peng, Peipei& Bai, Mei& Sun, Jiaqi…[et al.]. A Comparison of the Immunostimulatory Effects of Polysaccharides from Tetraploid and Diploid Echinacea purpurea. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1129255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129255