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Evaluating Vitamin D Status in Pre- and Postmenopausal Type 2 Diabetics and Its Association with Glucose Homeostasis
Joint Authors
Ephraim, Richard K. D.
Sakyi, Samuel A.
Owiredu, William K. B. A.
Laing, Edwin F.
Owiredu, Eddie-Williams
Fondjo, Linda Ahenkorah
Awusi, Ebenezer Kwesi
Kantanka, Osei Sarfo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Type 2 Diabetes Mellitus (T2DM) and menopause are associated with vitamin D status.
Oestrogen decline during menopausal stages promotes hypovitaminosis D.
However, the interplay between vitamin D, menopause, lifestyle, and T2DM cannot be overlooked.
This study assessed vitamin D status among pre- and postmenopausal T2DM women and determined its association with glycemic control and influence of lifestyle habits on hypovitaminosis D.
Methods.
This cross-sectional study was conducted at the Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Structured questionnaires were administered to 192 T2DM women; blood samples were collected for estimation of 25(OH) D and insulin using ELISA.
Fasting blood glucose (FBG), lipid profile, glycated haemoglobin (HbA1c), and calcium were measured.
Statistical analyses were performed using Graphpad Prism 6.
Results.
The prevalence of vitamin D inadequacy was 92.2%.
Hypovitaminosis D was more prevalent among the postmenopausal T2DM women (63.8% versus 58.2%).
Hypovitaminosis D significantly associated with insulin [R2=0.01760, p=0.0008], HbA1c [R2=0.3709, p=<0.0001], and FBG [R2=0.3465, p=0.0001] in only the postmenopausal women.
Conclusion.
Vitamin D deficiency is prevalent in pre- and postmenopausal T2DM but higher among postmenopausal women.
Adequate vitamin D levels in both groups were associated with improved glucose control while hypovitaminosis D in the postmenopausal women was related to poorer glucose control.
Vitamin D screening should be incorporated into management plan for T2DM to serve as an early tool for prevention of vitamin D deficiency.
American Psychological Association (APA)
Fondjo, Linda Ahenkorah& Sakyi, Samuel A.& Owiredu, William K. B. A.& Laing, Edwin F.& Owiredu, Eddie-Williams& Awusi, Ebenezer Kwesi…[et al.]. 2018. Evaluating Vitamin D Status in Pre- and Postmenopausal Type 2 Diabetics and Its Association with Glucose Homeostasis. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1129702
Modern Language Association (MLA)
Fondjo, Linda Ahenkorah…[et al.]. Evaluating Vitamin D Status in Pre- and Postmenopausal Type 2 Diabetics and Its Association with Glucose Homeostasis. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1129702
American Medical Association (AMA)
Fondjo, Linda Ahenkorah& Sakyi, Samuel A.& Owiredu, William K. B. A.& Laing, Edwin F.& Owiredu, Eddie-Williams& Awusi, Ebenezer Kwesi…[et al.]. Evaluating Vitamin D Status in Pre- and Postmenopausal Type 2 Diabetics and Its Association with Glucose Homeostasis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1129702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129702