The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Joint Authors
Kitae, Aya
Hashimoto, Yoshitaka
Hamaguchi, Masahide
Obora, Akihiro
Kojima, Takao
Fukui, Michiaki
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The triglyceride and glucose index (TyG), defined as the product of triglycerides (TG) and fasting plasma glucose (FPG), is reported as a surrogate index for insulin resistance.
Although a cross-sectional study revealed the association between the TyG-index and the prevalence of nonalcoholic fatty liver disease (NAFLD), few studies have investigated the association between the TyG-index and incident NAFLD.
Here we investigated whether the TyG-index can be used to predict incident NAFLD.
Methods.
This historical cohort study included 16,093 apparently healthy Japanese individuals.
The TyG-index was calculated by the established formula: TyG = Ln [TG (mg/dl) × FPG (mg/dl)/2].
Fatty liver was diagnosed based on the subjects’ abdominal ultrasonography results.
We divided the subjects into tertiles according to the levels of TyG-index.
Hazard ratios (HRs) of the TyG-index for incident NAFLD were calculated by a Cox proportional hazards regression model.
Results.
During the observation period, 27.4% of the men and 11.0% of the women developed NAFLD.
The highest TyG-index tertile (men, 8.48 ≤ TyG and women, 7.97 ≤ TyG) (adjusted HR 1.67, 95% CI 1.44–1.94, p<0.001 in the men and 2.06, 1.59–2.70, p<0.001 in the women) and the middle TyG-index tertile (men, 8.00 < TyG ≤ 8.48 and women, 7.53 Conclusions. Our findings demonstrate that the TyG-index is significantly associated with incident NAFLD.
American Psychological Association (APA)
Kitae, Aya& Hashimoto, Yoshitaka& Hamaguchi, Masahide& Obora, Akihiro& Kojima, Takao& Fukui, Michiaki. 2019. The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1129851
Modern Language Association (MLA)
Kitae, Aya…[et al.]. The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1129851
American Medical Association (AMA)
Kitae, Aya& Hashimoto, Yoshitaka& Hamaguchi, Masahide& Obora, Akihiro& Kojima, Takao& Fukui, Michiaki. The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1129851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129851