Association between Smoking and Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease
Joint Authors
Ou, Hongjie
Fu, Yaojie
Liao, Wei
Zheng, Caixia
Wu, Xiaolu
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
We aimed at analyzing the role of smoking in hepatic fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) and at exploring the related risk factors.
Methods.
This was a cross-sectional study that included a total of 225 patients with NAFLD.
Among them, 127 were nonsmokers and 98 were smokers.
Liver significant fibrosis was diagnosed when the liver stiffness (LS) value was higher than 7.4 kPa.
The diagnostic criterion for NAFLD was a controlled attenuation parameter (CAP) value of >238 dB/m.
The CAP and LS values were measured using FibroScan.
Results.
FibroScan showed that the LS value in the smokers was significantly higher than that in the nonsmokers (10.12 ± 10.38 kPa vs.
7.26 ± 6.42 kPa, P=0.013).
The proportions of patients with liver significant fibrosis and advanced liver fibrosis among the smokers were significantly higher than those among the nonsmokers (P=0.046).
Univariate analysis showed that age, weight, high AST level, low PLT level, and smoking were the risk factors associated with liver fibrosis in the smokers with NAFLD while multivariate analysis showed that age (OR = 1.029, P=0.021), high AST level (OR = 1.0121, P=0.025), and smoking (OR = 1.294, P=0.015) were the independent risk factors associated with liver fibrosis in the patients with NAFLD.
Moreover, high AST level (OR = 1.040, P=0.029), smoking index (OR = 1.220, P=0.019), and diabetes mellitus (OR = 1.054, P=0.032) were the independent risk factors for liver fibrosis among the smokers with NAFLD.
Conclusion.
This study showed that smoking was closely associated with liver fibrosis among the patients with NAFLD.
For patients with NAFLD who smoke, priority screening and timely intervention should be provided if they are at risk of liver fibrosis.
American Psychological Association (APA)
Ou, Hongjie& Fu, Yaojie& Liao, Wei& Zheng, Caixia& Wu, Xiaolu. 2019. Association between Smoking and Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1129883
Modern Language Association (MLA)
Ou, Hongjie…[et al.]. Association between Smoking and Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1129883
American Medical Association (AMA)
Ou, Hongjie& Fu, Yaojie& Liao, Wei& Zheng, Caixia& Wu, Xiaolu. Association between Smoking and Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1129883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129883