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Weight Loss in Parkinson’s Disease: The Relationship with Motor Symptoms and Disease Progression
Joint Authors
Cersosimo, Maria Graciela
Raina, Gabriela B.
Pellene, Luis A.
Micheli, Federico E.
Calandra, Cristian R.
Maiola, Ricardo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
To determine the prevalence of weight loss (WL) in PD patients, its relationship to the severity of motor manifestations and appetite changes.
Methods.
144 PD patients and 120 controls were evaluated in a single session.
All subjects were asked about changes in body weight and appetite.
PD patients were examined with the UPDRS-III and the Hoehn and Yahr (HY) scales.
Subscores of tremor, bradykinesia /rigidity, and non-dopaminergic symptoms (NDS) were analyzed individually.
Multivariable logistic regression analysis was used to determine an association between WL and PD motor manifestations.
Results.
48.6 % of PD patients presented WL compared to 20.8 % of controls (p < 0.001).
Weight losers were significantly older and had longer disease duration, higher scores in HY stages, UPDRS-III, and NDS-subscore.
Multivariable logistic regression analysis demonstrated that WL was associated with NDS-subscore (p= 0.002; OR: 1.33) and older age (p= 0.037; OR: 1.05).
Appetite in PD cases losing weight was unchanged (35.7 %), decreased (31.4 %), or even increased (32.9).
Conclusions.
Our results showed that WL occurs in almost half of PD patients and it is largely the consequence of disease progression rather than involuntary movements or a decrease in food intake.
American Psychological Association (APA)
Cersosimo, Maria Graciela& Raina, Gabriela B.& Pellene, Luis A.& Micheli, Federico E.& Calandra, Cristian R.& Maiola, Ricardo. 2018. Weight Loss in Parkinson’s Disease: The Relationship with Motor Symptoms and Disease Progression. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129938
Modern Language Association (MLA)
Cersosimo, Maria Graciela…[et al.]. Weight Loss in Parkinson’s Disease: The Relationship with Motor Symptoms and Disease Progression. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1129938
American Medical Association (AMA)
Cersosimo, Maria Graciela& Raina, Gabriela B.& Pellene, Luis A.& Micheli, Federico E.& Calandra, Cristian R.& Maiola, Ricardo. Weight Loss in Parkinson’s Disease: The Relationship with Motor Symptoms and Disease Progression. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129938