Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer
Joint Authors
Qian, Hui
Xu, Wenrong
Yan, Yongmin
Zhang, Xu
Mao, Fei
Kang, Jingjing
Zhang, Li
Luo, Xiao
Ma, Xiangyu
Wang, Gaoying
Yang, Yanhui
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Mesenchymal stem cells (MSCs) therapy has been applied to a wide range of diseases with excessive immune response, including inflammatory bowel disease (IBD), owing to its powerful immunosuppression and its ability to repair tissue lesions.
Different sources of MSCs show different therapeutic properties.
Engineering managements are able to enhance the immunomodulation function and the survival of MSCs involved in IBD.
The therapeutic mechanism of MSCs in IBD mainly focuses on cell-to-cell contact and paracrine actions.
One of the promising therapeutic options for IBD can focus on exosomes of MSCs.
MSCs hold promise for the treatment of IBD-associated colorectal cancer because of their tumor-homing function and chronic inflammation inhibition.
Encouraging results have been obtained from clinical trials in IBD and potential challenges caused by MSCs therapy are getting solved.
This review can assist investigators better to understand the research progress for enhancing the efficacy of MSCs therapy involved in IBD and CAC.
American Psychological Association (APA)
Kang, Jingjing& Zhang, Li& Luo, Xiao& Ma, Xiangyu& Wang, Gaoying& Yang, Yanhui…[et al.]. 2018. Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer. BioMed Research International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1129955
Modern Language Association (MLA)
Kang, Jingjing…[et al.]. Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer. BioMed Research International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1129955
American Medical Association (AMA)
Kang, Jingjing& Zhang, Li& Luo, Xiao& Ma, Xiangyu& Wang, Gaoying& Yang, Yanhui…[et al.]. Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1129955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129955