Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation
Joint Authors
Yang, Li
Men, Ruoting
Shen, Yi
Lu, Changli
Liu, Jianping
Ye, Tinghong
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aim.
To study the differences between acute presentation-autoimmune hepatitis (A-AIH) and chronic autoimmune hepatitis (C-AIH).
Methods.
Through long-term follow-up, 80 patients were included in our study by using the revised international autoimmune hepatitis group (IAIHG) score and were divided into acute and chronic groups for comparison.
Results.
No significant difference was found in the gender, age, IAIHG score (pretreatment/posttreatment), definite diagnosis rate, extrahepatic autoimmune disease, onset time, or treatment before biopsy between the acute and chronic groups.
In terms of clinical symptoms, A-AIH patients were more prone to jaundice, anorexia, yellow urine, and detesting oil than C-AIH patients, but melena only occurred in chronic group (P<0.05).
The acute group exhibited more severe injury upon histological evaluation, with lobular inflammation and bile duct injury, especially central necrosis of the lobule, more pronounced in this group (P<0.05).
Conclusion.
A-AIH had manifestations of acute hepatitis and presented cholestasis.
Serum indicators could preliminarily distinguish A-AIH and C-AIH.
Histologically, the primary manifestation of A-AIH was lobular inflammation, which was usually accompanied by lobular central necrosis.
For the diagnosis of A-AIH, more attention should be paid to long-term follow-up.
This study was registered at ClinicalTrials.gov (identifier: NCT02994537).
American Psychological Association (APA)
Shen, Yi& Lu, Changli& Men, Ruoting& Liu, Jianping& Ye, Tinghong& Yang, Li. 2018. Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130898
Modern Language Association (MLA)
Shen, Yi…[et al.]. Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1130898
American Medical Association (AMA)
Shen, Yi& Lu, Changli& Men, Ruoting& Liu, Jianping& Ye, Tinghong& Yang, Li. Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130898