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Evaluating Adherence to Antiretroviral Therapy Using Pharmacy Refill Records in a Rural Treatment Site in South Africa
Joint Authors
Bessong, Pascal O.
Gachara, George
Mavhandu, Lufuno G.
Rogawski, Elizabeth T.
Manhaeve, Cecile
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Optimal adherence to combination antiretroviral therapy (cART) is critical to maintain virologic suppression, thereby ensuring the global success of HIV treatment.
We evaluated adherence to cART using pharmacy refill records and determined the adherence threshold resulting in >90% virologic suppression in a community run treatment site in South Africa.
Additionally, we analysed factors associated with adherence using univariable and multivariable logistic regression models.
Logistic regression was also performed to determine the relationship between adherence and virologic suppression and the adherence threshold resulting in <10% virologic failure.
The overall median (interquartile range) adherence was 95% (88.6–98.4%).
Out of the study participants, 210/401 (52.4%) had optimal (≥95%) adherence while only 37/401 (9.2%) had poor (≤80%) adherence.
The majority (90.5%) of patients with optimal adherence had virologic suppression.
Having TB at registration into care was found to be negatively associated with adherence (adjusted odds ratio [AOR], 0.382; p≤.05).
Compared to nonadherent individuals, optimally adherent participants were more likely to achieve virologic suppression (OR 2.92; 95% CI: 1.63–5.22).
Only adherence rates above 95% were observed to lead to <10% virologic failure.
cART adherence measured by pharmacy refill records could serve as a useful predictor of virologic failure; adherence rates >95% are needed to maintain optimal virologic suppression.
American Psychological Association (APA)
Gachara, George& Mavhandu, Lufuno G.& Rogawski, Elizabeth T.& Manhaeve, Cecile& Bessong, Pascal O.. 2017. Evaluating Adherence to Antiretroviral Therapy Using Pharmacy Refill Records in a Rural Treatment Site in South Africa. AIDS Research and Treatment،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1130937
Modern Language Association (MLA)
Gachara, George…[et al.]. Evaluating Adherence to Antiretroviral Therapy Using Pharmacy Refill Records in a Rural Treatment Site in South Africa. AIDS Research and Treatment No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1130937
American Medical Association (AMA)
Gachara, George& Mavhandu, Lufuno G.& Rogawski, Elizabeth T.& Manhaeve, Cecile& Bessong, Pascal O.. Evaluating Adherence to Antiretroviral Therapy Using Pharmacy Refill Records in a Rural Treatment Site in South Africa. AIDS Research and Treatment. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1130937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130937