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In Vitro Antibacterial Interaction of Doripenem and Amikacin against Multidrug-Resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae Isolates
Joint Authors
Loho, Tonny
Sukartini, Ninik
Astrawinata, Dalima A. W.
Immanuel, Suzanna
Aulia, Diana
Priatni, Ika
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Evaluation of the in vitro interaction of doripenem and amikacin against Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae was done by classifying them into four groups: doripenem and amikacin sensitive (DOR-S/AMK-S), doripenem sensitive and amikacin resistant (DOR-S/AMK-R), doripenem resistant and amikacin sensitive (DOR-R/AMK-S), and both doripenem and amikacin resistant (DOR-R/AMK-R).
The MIC of each antibiotic and their combination was obtained using the Etest method.
The fractional inhibitory concentration index was calculated to classify the results as synergistic, additive, indifferent, or antagonistic interaction.
In the DOR-S/AMK-S class, 1 isolate of A.
baumannii showed synergy and the other 5 showed additive results, 5 isolates of P.
aeruginosa showed additive and 1 isolate showed indifferent result, and 2 isolates of K.
pneumoniae showed additive and the other 4 showed indifferent results.
In the DOR-S/AMK-R class, 3 isolates of A.
baumannii showed additive and the other 3 showed indifferent results, 2 isolates of P.
aeruginosa showed indifferent results, and 1 isolate of K.
pneumoniae showed additive and the other 5 showed indifferent results.
In the DOR-R/AMK-S class, 1 isolate of A.
baumannii showed additive and the other 5 showed indifferent results, 1 isolate of P.
aeruginosa showed additive and the other 5 showed indifferent results, and 4 isolates of K.
pneumoniae showed additive and the other 2 showed indifferent results.
In the DOR-R/AMK-R class, 6 isolates of A.
baumannii showed indifferent results, 1 isolate of P.
aeruginosa showed additive and the other 5 showed indifferent results, and 1 isolate of K.
pneumoniae showed additive and the other 5 showed indifferent results.
Synergy occurred in only 1 (1.5%) isolate.
Additive interaction occurred in 24 (35.3%) isolates, and indifferent interaction occurred in 43 (63.2%) isolates.
Doripenem sensitive combined with amikacin sensitive reduced MIC significantly in all bacterial isolates when compared to single MIC of each antibiotic.
American Psychological Association (APA)
Loho, Tonny& Sukartini, Ninik& Astrawinata, Dalima A. W.& Immanuel, Suzanna& Aulia, Diana& Priatni, Ika. 2018. In Vitro Antibacterial Interaction of Doripenem and Amikacin against Multidrug-Resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae Isolates. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1131117
Modern Language Association (MLA)
Loho, Tonny…[et al.]. In Vitro Antibacterial Interaction of Doripenem and Amikacin against Multidrug-Resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae Isolates. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1131117
American Medical Association (AMA)
Loho, Tonny& Sukartini, Ninik& Astrawinata, Dalima A. W.& Immanuel, Suzanna& Aulia, Diana& Priatni, Ika. In Vitro Antibacterial Interaction of Doripenem and Amikacin against Multidrug-Resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae Isolates. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1131117
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131117