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Prevalence and Risk Factors of Active TB among Adult HIV Patients Receiving ART in Northwestern Tanzania: A Retrospective Cohort Study
Joint Authors
Shao, Elichilia
Mpondo, Bonaventura C. T.
Kalluvya, Samuel
Gunda, Daniel W.
Kilonzo, Semvua B.
Maganga, Simon C.
Nkandala, Igembe
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Although ART has improved the outcome of people living with HIV/AIDS, still some patients develop TB while receiving ART.
The literature on the magnitude of this problem is still scarce in our setting especially northwestern Tanzania.
This study was designed to determine the prevalence of active TB among HIV patients on ART and assess its potential risk factors.
Methods.
A retrospective cohort study was done among adult HIV-positive patients initiated on ART at Bugando Medical Centre.
Patients who were TB positive before ART initiation were excluded.
Data regarding demographic, clinical, and laboratory information, TB status on receipt of ART, and time on ART were collected and analyzed using STATA 11 to determine the prevalence of TB and its associated factors.
Results.
In total, 391 patients were enrolled in this study.
The median age was 39 (32–46) years, and a total of 129 (32.99%) participants had CD4 counts <200 cells/µl and 179 (45.78%) had WHO stage 3 and 4 illnesses.
A total of 43 (11.0%) participants developed TB while receiving ART which was independently associated with male gender (OR = 2.9; p=0.007), WHO clinical stage 3 and 4 (OR = 1.4; p=0.029), baseline CD4 count <200 cells/µl (OR = 9.1; p<0.001), and having not used IPT (OR = 3.1; p=0.05).
Conclusions.
Active TB is prevalent among HIV patients while receiving ART in northwestern Tanzania which is independently associated with male gender, advanced HIV disease, and nonuse of IPT.
Universal HIV testing could reduce late HIV diagnosis and hence reduce the risk of developing TB while receiving ART in our setting.
Also IPT should be widely used for those who are negative for TB on screening.
American Psychological Association (APA)
Gunda, Daniel W.& Maganga, Simon C.& Nkandala, Igembe& Kilonzo, Semvua B.& Mpondo, Bonaventura C. T.& Shao, Elichilia…[et al.]. 2018. Prevalence and Risk Factors of Active TB among Adult HIV Patients Receiving ART in Northwestern Tanzania: A Retrospective Cohort Study. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131119
Modern Language Association (MLA)
Gunda, Daniel W.…[et al.]. Prevalence and Risk Factors of Active TB among Adult HIV Patients Receiving ART in Northwestern Tanzania: A Retrospective Cohort Study. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1131119
American Medical Association (AMA)
Gunda, Daniel W.& Maganga, Simon C.& Nkandala, Igembe& Kilonzo, Semvua B.& Mpondo, Bonaventura C. T.& Shao, Elichilia…[et al.]. Prevalence and Risk Factors of Active TB among Adult HIV Patients Receiving ART in Northwestern Tanzania: A Retrospective Cohort Study. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131119