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Prognostic Value of Volume-Based Positron Emission TomographyComputed Tomography in Nasopharyngeal Carcinoma Patients after Comprehensive Therapy
Joint Authors
Zhang, Yongxue
Lan, Xiaoli
Tian, Yueli
Bakari, Khamis Hassan
Liao, Shanshan
Xia, Xiaotian
Sun, Xun
Qin, Chunxia
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
We assessed the prognostic value of standardized uptake value (SUV) and volume-based methods including whole-body metabolic tumor volume (WBMTV) and whole-body total lesion glycolysis (WBTLG) using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) of patients with nasopharyngeal carcinoma (NPC) after therapy.
Methods.
A total of 221 posttherapy NPC cases were enrolled, all of whom had undergone PET/CT scanning and follow-up in this retrospective study.
The diagnostic results of PET/CT were analyzed and compared with histopathological diagnosis or clinical follow-up.
Receiver operator characteristic curves, the Kaplan-Meier method, and the log-rank test were used to assess the optimal cutoff values for WBMTV and WBTLG to identify independent predictors of survival.
Results.
The detection rates of the threshold SUV were 2.5, 20%, and 40%, and SUV background methods were 65.6% (378/576), 80.2% (462/576), 71.5% (412/576), and 90.4% (521/576), respectively (P<0.005).
Patients with a WBMTV < 8.10 and/or a WBTLG < 35.58 had significantly better 5-year overall survival than those above the cutoffs (90.7% versus 51.2%, P<0.001; 91.7% versus 50.4%, P<0.001), respectively.
Multivariate Cox regression modeling showed both WBTLG (RR, 1.002; P=0.004) and age (RR, 1.046; P=0.006) could be used to predict overall survival.
WBTLG (RR, 1.003; P<0.001) may have predictive relevance in estimating disease-free survival.
Conclusions.
SUV volume-based threshold background methodology had a significantly higher detection rate for metastatic lesions.
WBTLG could be used as an independent prognostic indicator for posttherapy NPC.
American Psychological Association (APA)
Tian, Yueli& Bakari, Khamis Hassan& Liao, Shanshan& Xia, Xiaotian& Sun, Xun& Qin, Chunxia…[et al.]. 2018. Prognostic Value of Volume-Based Positron Emission TomographyComputed Tomography in Nasopharyngeal Carcinoma Patients after Comprehensive Therapy. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1131291
Modern Language Association (MLA)
Tian, Yueli…[et al.]. Prognostic Value of Volume-Based Positron Emission TomographyComputed Tomography in Nasopharyngeal Carcinoma Patients after Comprehensive Therapy. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1131291
American Medical Association (AMA)
Tian, Yueli& Bakari, Khamis Hassan& Liao, Shanshan& Xia, Xiaotian& Sun, Xun& Qin, Chunxia…[et al.]. Prognostic Value of Volume-Based Positron Emission TomographyComputed Tomography in Nasopharyngeal Carcinoma Patients after Comprehensive Therapy. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1131291
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131291