Attenuation of Cortically Evoked Motor-Neuron Potential in Streptozotocin-Induced Diabetic Rats: A Study about the Effect of Diabetes upon Cortical-Initiated Movement
Joint Authors
Pedersen, Michael
Madsen, Jesper Guldsmed
Andersen, Henning
Østergaard, Jakob Appel
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aims/Hypothesis.
The complications affecting the peripheral nervous system, associated with diabetes mellitus, have been the focus of considerable research.
Comparably less research has focused upon the effect of diabetes upon the central nervous system.
In this study, we investigate the effect of diabetes upon motor-neuron potentials evoked in the motor cortex of streptozotocin diabetic rats.
Methods.
In this study, we investigated the cortical-evoked motor-neuron potentials in streptozotocin-induced diabetic rats.
Cortical potentials were evoked using direct current stimulation to the motor cortex, and the resulting evoked potentials were recorded in the sciatic nerve.
As voluntary movement consists of repeated activation of muscles, repeated stimulation trials were used to determine the effect of diabetes upon the animals’ ability to recuperate between stimulations.
Results.
Our findings showed that diabetes severely decreased the amplitude of cortical-evoked potentials and compromised the recuperation of motor neurons between activation.
Conclusion/Interpretation.
The reduced amplitude and weakened recuperation of diabetic motor neurons potentially may contribute to impaired transmission in motor pathways and thereby motor dysfunction.
American Psychological Association (APA)
Madsen, Jesper Guldsmed& Østergaard, Jakob Appel& Andersen, Henning& Pedersen, Michael. 2020. Attenuation of Cortically Evoked Motor-Neuron Potential in Streptozotocin-Induced Diabetic Rats: A Study about the Effect of Diabetes upon Cortical-Initiated Movement. BioMed Research International،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1132176
Modern Language Association (MLA)
Madsen, Jesper Guldsmed…[et al.]. Attenuation of Cortically Evoked Motor-Neuron Potential in Streptozotocin-Induced Diabetic Rats: A Study about the Effect of Diabetes upon Cortical-Initiated Movement. BioMed Research International No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1132176
American Medical Association (AMA)
Madsen, Jesper Guldsmed& Østergaard, Jakob Appel& Andersen, Henning& Pedersen, Michael. Attenuation of Cortically Evoked Motor-Neuron Potential in Streptozotocin-Induced Diabetic Rats: A Study about the Effect of Diabetes upon Cortical-Initiated Movement. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1132176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132176