Significance of Hepatitis B Recurrence in Liver Transplantation Recipients
Joint Authors
Lee, Wei-Chen
Wu, Tsung-Han
Wang, Yu-Chao
Chou, Hong-Shiue
Hung, Hao-Chien
Lee, Jin-Chiao
Lee, Chen-Fang
Chan, Kun-Ming
Wu, Ting-Jung
Cheng, Chih-Hsien
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
A combination of antihepatitis B immunoglobulin and antiviral agents is the most common regimen for prophylaxis of hepatitis B recurrence after liver transplantation.
However, hepatitis B recurrence still happens.
The significance of hepatitis B recurrence is less mentioned.
Materials.
Forty-eight of the 313 hepatitis B liver transplant recipients having hepatitis B recurrence were included in this study.
The patients were divided into group A, the patients transplanted for hepatitis B-related liver failure, and group B, the patients transplanted for hepatitis B-related cirrhosis and HCC.
The clinical manifestations after hepatitis B recurrence were recorded.
Results.
Among the 48 patients with hepatitis B recurrence, 23 patients were in group A and 25 patients in group B.
The age was 51.6±9.4 years in group A and 52.8±6.4 in group B (p=0.869).
The MELD score prior to transplantation was 23.1±9.9 in group A patients and 12.9±5.6 in group B patients (p<0.001).
The median (interquartile) interval from transplantation to hepatitis B recurrence was 10 (2-19) months for group A patients and 13 (8.5-35) months for group B patients (p=0.051).
After hepatitis B recurrence, the liver function was almost normal in both groups.
In group B patients, 10 patients had HCC recurrence with 7 of 10 patients having hepatitis B recurrence earlier than HCC recurrence.
The interval between hepatitis B and HCC recurrence was 1 to 15 months.
The 1-, 3-, and 5-year survival rates were 82.6%, 73.9%, and 69.0%, respectively, for group A patients and 96%, 76%, and 68%, respectively, for group B patients (p=0.713).
Conclusion.
The patients have uneventful liver function under antiviral agent while hepatitis B recurred.
For the patients having HCC prior to transplantation, close monitoring of HCC recurrence is necessary if hepatitis B recurs.
American Psychological Association (APA)
Chou, Hong-Shiue& Cheng, Chih-Hsien& Hung, Hao-Chien& Lee, Jin-Chiao& Wang, Yu-Chao& Wu, Tsung-Han…[et al.]. 2020. Significance of Hepatitis B Recurrence in Liver Transplantation Recipients. BioMed Research International،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1132546
Modern Language Association (MLA)
Chou, Hong-Shiue…[et al.]. Significance of Hepatitis B Recurrence in Liver Transplantation Recipients. BioMed Research International No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1132546
American Medical Association (AMA)
Chou, Hong-Shiue& Cheng, Chih-Hsien& Hung, Hao-Chien& Lee, Jin-Chiao& Wang, Yu-Chao& Wu, Tsung-Han…[et al.]. Significance of Hepatitis B Recurrence in Liver Transplantation Recipients. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1132546
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132546