![](/images/graphics-bg.png)
High-Density Lipoprotein Cholesterol, Blood Urea Nitrogen, and Serum Creatinine Can Predict Severe Acute Pancreatitis
Joint Authors
Zhou, Mengtao
Geng, Wujun
Hong, Wandong
Lin, Suhan
Zippi, Maddalena
Stock, Simon
Zimmer, Vincent
Xu, Chunfang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aims.
Early prediction of disease severity of acute pancreatitis (AP) would be helpful for triaging patients to the appropriate level of care and intervention.
The aim of the study was to develop a model able to predict Severe Acute Pancreatitis (SAP).
Methods.
A total of 647 patients with AP were enrolled.
The demographic data, hematocrit, High-Density Lipoprotein Cholesterol (HDL-C) determinant at time of admission, Blood Urea Nitrogen (BUN), and serum creatinine (Scr) determinant at time of admission and 24 hrs after hospitalization were collected and analyzed statistically.
Results.
Multivariate logistic regression indicated that HDL-C at admission and BUN and Scr at 24 hours (hrs) were independently associated with SAP.
A logistic regression function (LR model) was developed to predict SAP as follows: −2.25–0.06 HDL-C (mg/dl) at admission + 0.06 BUN (mg/dl) at 24 hours + 0.66 Scr (mg/dl) at 24 hours.
The optimism-corrected c-index for LR model was 0.832 after bootstrap validation.
The area under the receiver operating characteristic curve for LR model for the prediction of SAP was 0.84.
Conclusions.
The LR model consists of HDL-C at admission and BUN and Scr at 24 hours, representing an additional tool to stratify patients at risk of SAP.
American Psychological Association (APA)
Hong, Wandong& Lin, Suhan& Zippi, Maddalena& Geng, Wujun& Stock, Simon& Zimmer, Vincent…[et al.]. 2017. High-Density Lipoprotein Cholesterol, Blood Urea Nitrogen, and Serum Creatinine Can Predict Severe Acute Pancreatitis. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134096
Modern Language Association (MLA)
Hong, Wandong…[et al.]. High-Density Lipoprotein Cholesterol, Blood Urea Nitrogen, and Serum Creatinine Can Predict Severe Acute Pancreatitis. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1134096
American Medical Association (AMA)
Hong, Wandong& Lin, Suhan& Zippi, Maddalena& Geng, Wujun& Stock, Simon& Zimmer, Vincent…[et al.]. High-Density Lipoprotein Cholesterol, Blood Urea Nitrogen, and Serum Creatinine Can Predict Severe Acute Pancreatitis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134096