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Association of Urine AlbuminCreatinine Ratio below 30 mgg and Left Ventricular Hypertrophy in Patients with Type 2 Diabetes
Joint Authors
Lai, Wenyan
Xie, Xiangkun
Peng, Zhengliang
Li, Hanlin
Li, Dan
Tu, Yan
Bai, Yujia
Huang, Xingfu
Zhan, Qiong
Zeng, Qingchun
Xu, Dingli
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Several studies show that even a level of urine albumin/creatinine ratio (UACR) within the normal range (below 30 mg/g) increases the risk of cardiovascular diseases.
We speculate that mildly increased UACR is related to left ventricular hypertrophy (LVH) in patients with type 2 diabetes mellitus (T2DM).
In this retrospective study, 317 patients with diabetes with normal UACR, of whom 62 had LVH, were included.
The associations between UACR and laboratory indicators, as well as LVH, were examined using multivariate linear regression and logistic regression, respectively.
The diagnostic efficiency and the optimal cutoff point of UACR for LVH were evaluated using the area under the receiver operating characteristic curve (AUC) and Youden index.
Our results showed that patients with LVH had significantly higher UACR than those without LVH (P<0.001).
The prevalence of LVH presented an upward trend with the elevation of UACR.
UACR was independently and positively associated with hemoglobin A1c (P<0.001).
UACR can differentiate LVH (AUC = 0.682, 95% CI (0.602–0.760), P<0.001).
The optimal cutoff point determined with the Youden index was UACR = 10.2 mg/g.
When categorized by this cutoff point, the odds ratio (OR) for LVH in patients in the higher UACR group (10.2–30 mg/g) was 3.104 (95% CI: 1.557–6.188, P=0.001) compared with patients in the lower UACR group (<10.2 mg/g).
When UACR was analyzed as a continuous variable, every double of increased UACR, the OR for LVH was 1.511 (95% CI: 1.047–2.180, P=0.028).
Overall, UACR below 30 mg/g is associated with LVH in patients with T2DM.
The optimal cutoff value of UACR for identifying LVH in diabetes is 10 mg/g.
American Psychological Association (APA)
Xie, Xiangkun& Peng, Zhengliang& Li, Hanlin& Li, Dan& Tu, Yan& Bai, Yujia…[et al.]. 2020. Association of Urine AlbuminCreatinine Ratio below 30 mgg and Left Ventricular Hypertrophy in Patients with Type 2 Diabetes. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134604
Modern Language Association (MLA)
Xie, Xiangkun…[et al.]. Association of Urine AlbuminCreatinine Ratio below 30 mgg and Left Ventricular Hypertrophy in Patients with Type 2 Diabetes. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1134604
American Medical Association (AMA)
Xie, Xiangkun& Peng, Zhengliang& Li, Hanlin& Li, Dan& Tu, Yan& Bai, Yujia…[et al.]. Association of Urine AlbuminCreatinine Ratio below 30 mgg and Left Ventricular Hypertrophy in Patients with Type 2 Diabetes. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134604