Toxicity Studies of Ethyl Maltol and Iron Complexes in Mice
Joint Authors
Chen, Jia
Nan, Ruipeng
Li, Zhen
Lu, Jieli
Wu, Chonghui
Pang, Quanhai
Zhu, Zhiwei
Du, Ruochen
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ethyl maltol and iron complexes are products of ethyl maltol and the iron found in the cooking pots used to prepare the Chinese dish, hot-pot.
Because their safety is undocumented, the toxicity study of ethyl maltol and iron complexes was conducted in male and female Kunming (KM) mice.
The animal study was designed based on the preliminary study conducted to determine the median lethal dose (LD50).
The doses used in the study were 0, 1/81, 1/27, 1/9, and 1/3 of the LD50 (mg kg body weight (BW)−1 day−1) dissolved in the water.
The oral LD50 of the ethyl maltol and iron complexes was determined to be 743.88 mg kg BW−1 in mice.
The ethyl maltol and iron complexes targeted the endocrine organs including the liver and kidneys following the 90 D oral exposure.
Based on the haematological data, the lowest-observed-adverse-effect level (LOAEL) of the ethyl maltol and iron complexes was determined to be 1/81 LD50 (9.18 mg kg BW−1 day−1) in both male and female mice.
Therefore, we suggest that alternative strategies for preparing the hot-pot, including the use of non-Fe-based cookware, need to be developed and encouraged to avoid the formation of the potentially toxic complexes.
American Psychological Association (APA)
Li, Zhen& Lu, Jieli& Wu, Chonghui& Pang, Quanhai& Zhu, Zhiwei& Nan, Ruipeng…[et al.]. 2017. Toxicity Studies of Ethyl Maltol and Iron Complexes in Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134998
Modern Language Association (MLA)
Li, Zhen…[et al.]. Toxicity Studies of Ethyl Maltol and Iron Complexes in Mice. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1134998
American Medical Association (AMA)
Li, Zhen& Lu, Jieli& Wu, Chonghui& Pang, Quanhai& Zhu, Zhiwei& Nan, Ruipeng…[et al.]. Toxicity Studies of Ethyl Maltol and Iron Complexes in Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134998