![](/images/graphics-bg.png)
Evaluation of Stability and In Vitro Security of Nanoemulsions Containing Eucalyptus globulus Oil
Joint Authors
Ourique, A. F.
de Godoi, Samantha Nunes
Quatrin, Priscilla Maciel
Sagrillo, Michele Rorato
Nascimento, Kátia
Klein, Bruna
Santos, Roberto Christ Vianna
Wagner, Roger
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Essential oil of Eucalyptus globulus presents several pharmacological properties.
However, their therapeutic efficacy may be affected by limitations due to several conditions, rendering it difficult to obtain stable and effective pharmaceutical formulations.
The use of nanotechnology is an alternative to improve their characteristics aiming to ensure their stability and effectiveness.
Furthermore, studies about the possible toxic effects of nanostructures are necessary to evaluate safety when the formulation comes into contact with human cells.
Hence, in this paper, we evaluate for the first time the stability and in vitro cytogenotoxicity of nanoemulsions containing Eucalyptus globulus in peripheral blood mononuclear cells.
As a result, the stability study found that the best condition for storage up to 90 days was refrigeration (4°C); it was the condition that best preserved the nanometric features.
The content of the major compounds of oil was maintained after nanoencapsulation and preserved over time.
In tests to evaluate the safety of this formulation, we can conclude that, at a low concentration (approximately 0.1%), Eucalyptus globulus nanoemulsion did not cause toxicity in peripheral blood mononuclear cells and also showed a protective effect in cells against possible damage when compared to oil in free form.
American Psychological Association (APA)
de Godoi, Samantha Nunes& Quatrin, Priscilla Maciel& Sagrillo, Michele Rorato& Nascimento, Kátia& Wagner, Roger& Klein, Bruna…[et al.]. 2017. Evaluation of Stability and In Vitro Security of Nanoemulsions Containing Eucalyptus globulus Oil. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1135077
Modern Language Association (MLA)
de Godoi, Samantha Nunes…[et al.]. Evaluation of Stability and In Vitro Security of Nanoemulsions Containing Eucalyptus globulus Oil. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1135077
American Medical Association (AMA)
de Godoi, Samantha Nunes& Quatrin, Priscilla Maciel& Sagrillo, Michele Rorato& Nascimento, Kátia& Wagner, Roger& Klein, Bruna…[et al.]. Evaluation of Stability and In Vitro Security of Nanoemulsions Containing Eucalyptus globulus Oil. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1135077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135077