Interleukin-9 Promotes Pancreatic Cancer Cells Proliferation and Migration via the miR-200aBeta-Catenin Axis
Joint Authors
Hu, Bangli
Qiu-lan, Huang
Lei, Rong-e
Shi, Cheng
Jiang, Hai-xing
Qin, Shan-yu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Both IL-9 and miR-200a are involved in the pathogenesis of cancers; however, the role of IL-9 in pancreatic cancer and the possible underlying mechanisms remain unknown.
The aim of this study was to investigate the effect of IL-9 on pancreatic cancer cells and its interaction with miR-200a.
Methods.
Pancreatic cancer cells (PANC-1 and AsPC-1) were treated with IL-9 and the expression of miR-200a and β-catenin in pancreatic cancer cells was measured.
β-Catenin was examined as a target gene of miR-200a in pancreatic cancer cells.
The interaction between IL-9 and miR-200a in pancreatic cancer cells was determined by infecting miR-200a mimics prior to IL-9 treatment and then measuring miR-200a and β-catenin expression.
Results.
IL-9 significantly promoted the proliferation, invasion, and migration of pancreatic cancer cells; however, the effect on pancreatic cancer cell apoptosis was insignificant.
β-Catenin was verified as a target gene of miR-200a in pancreatic cancer cells.
Overexpression of miR-200a in pancreatic cancer cells significantly attenuated proliferation and metastasis and reduced β-catenin expression.
IL-9 treatment of pancreatic cancer cells decreased miR-200a expression and increased β-catenin expression.
The effect of miR-200a on pancreatic cancer cells decreased following IL-9 treatment.
Conclusions.
IL-9 promotes proliferation and metastasis in pancreatic cancer cells; this effect may partly involve regulation of the miR-200a/β-catenin axis.
American Psychological Association (APA)
Hu, Bangli& Qiu-lan, Huang& Lei, Rong-e& Shi, Cheng& Jiang, Hai-xing& Qin, Shan-yu. 2017. Interleukin-9 Promotes Pancreatic Cancer Cells Proliferation and Migration via the miR-200aBeta-Catenin Axis. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1135448
Modern Language Association (MLA)
Hu, Bangli…[et al.]. Interleukin-9 Promotes Pancreatic Cancer Cells Proliferation and Migration via the miR-200aBeta-Catenin Axis. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1135448
American Medical Association (AMA)
Hu, Bangli& Qiu-lan, Huang& Lei, Rong-e& Shi, Cheng& Jiang, Hai-xing& Qin, Shan-yu. Interleukin-9 Promotes Pancreatic Cancer Cells Proliferation and Migration via the miR-200aBeta-Catenin Axis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1135448
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135448