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Alternative Polyadenylation Modification Patterns Reveal Essential Posttranscription Regulatory Mechanisms of Tumorigenesis in Multiple Tumor Types
Joint Authors
Feng, Kaiyan
Huang, Tao
Zhang, Yu-Hang
Zeng, Tao
Li, Min
Pan, XiaoYong
Chen, Lei
Cai, Yu-Dong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Among various risk factors for the initiation and progression of cancer, alternative polyadenylation (APA) is a remarkable endogenous contributor that directly triggers the malignant phenotype of cancer cells.
APA affects biological processes at a transcriptional level in various ways.
As such, APA can be involved in tumorigenesis through gene expression, protein subcellular localization, or transcription splicing pattern.
The APA sites and status of different cancer types may have diverse modification patterns and regulatory mechanisms on transcripts.
Potential APA sites were screened by applying several machine learning algorithms on a TCGA-APA dataset.
First, a powerful feature selection method, minimum redundancy maximum relevancy, was applied on the dataset, resulting in a feature list.
Then, the feature list was fed into the incremental feature selection, which incorporated the support vector machine as the classification algorithm, to extract key APA features and build a classifier.
The classifier can classify cancer patients into cancer types with perfect performance.
The key APA-modified genes had a potential prognosis ability because of their significant power in the survival analysis of TCGA pan-cancer data.
American Psychological Association (APA)
Li, Min& Pan, XiaoYong& Zeng, Tao& Zhang, Yu-Hang& Feng, Kaiyan& Chen, Lei…[et al.]. 2020. Alternative Polyadenylation Modification Patterns Reveal Essential Posttranscription Regulatory Mechanisms of Tumorigenesis in Multiple Tumor Types. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1135804
Modern Language Association (MLA)
Li, Min…[et al.]. Alternative Polyadenylation Modification Patterns Reveal Essential Posttranscription Regulatory Mechanisms of Tumorigenesis in Multiple Tumor Types. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1135804
American Medical Association (AMA)
Li, Min& Pan, XiaoYong& Zeng, Tao& Zhang, Yu-Hang& Feng, Kaiyan& Chen, Lei…[et al.]. Alternative Polyadenylation Modification Patterns Reveal Essential Posttranscription Regulatory Mechanisms of Tumorigenesis in Multiple Tumor Types. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1135804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135804