Adequate Platelet Function Inhibition Confirmed by Two Inductive Agents Predicts Lower Recurrence of Ischemic StrokeTransient Ischemic Attack
Joint Authors
Fang, Qi
Kong, Yan
Cai, Xiuying
Zhang, Lulu
Hu, Xiaowei
Zhu, Juehua
Wang, Hui
Diao, Shanshan
Zhao, Hongru
Jiang, Jianhua
Wang, Dapeng
Zhang, Quanquan
Qin, Yiren
Yue, Wei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The correlation between platelet function and recurrent ischemic stroke or TIA remains uncertain.
Objective.
To investigate two inductive agents to detect platelet functions and assess associations with recurrent ischemic stroke/TIA.
Method.
The study included 738 ischemic stroke/TIA patients.
On days 0, 3, and 9 after antiplatelet therapy, platelet function tests were determined by maximum aggregation rate (MAR) using a PL-11 platelet function analyzer and phase matching reagents.
Two induction agents were used: arachidonic acid (AA) and adenosine diphosphate (ADP).
At 3-month follow-up, recurrence of stroke/TIA was recorded.
Result.
Cut-off values of adequate platelet function inhibition were MARADP < 35% and MARAA < 35%.
Data showed that antiplatelet therapy could reduce the maximum aggregation rate.
More importantly, adequate platelet function inhibition of either MARADP or MARAA was not associated with the recurrence of stroke/TIA, but adequate platelet function inhibition of not only MARADP but also MARAA predicts lower recurrence (0/121 (0.00%) versus 18/459 (3.92%), P = 0.0188).
Conclusion.
The platelet function tested by PL-11 demonstrated that adequate inhibition of both MARADP and MARAA could predict lower risk of ischemic stroke/TIA recurrence.
American Psychological Association (APA)
Zhang, Lulu& Hu, Xiaowei& Zhu, Juehua& Cai, Xiuying& Kong, Yan& Wang, Hui…[et al.]. 2017. Adequate Platelet Function Inhibition Confirmed by Two Inductive Agents Predicts Lower Recurrence of Ischemic StrokeTransient Ischemic Attack. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1136012
Modern Language Association (MLA)
Zhang, Lulu…[et al.]. Adequate Platelet Function Inhibition Confirmed by Two Inductive Agents Predicts Lower Recurrence of Ischemic StrokeTransient Ischemic Attack. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1136012
American Medical Association (AMA)
Zhang, Lulu& Hu, Xiaowei& Zhu, Juehua& Cai, Xiuying& Kong, Yan& Wang, Hui…[et al.]. Adequate Platelet Function Inhibition Confirmed by Two Inductive Agents Predicts Lower Recurrence of Ischemic StrokeTransient Ischemic Attack. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1136012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136012